Expect the unexpected:Brown tumor of the mandible as the first manifestation of primary hyperparathyroidism  

作　　者：Ana Majic Tengg Maja Cigrovski Berkovic Ivan Zajc Ivan Salaric Danko Müller Iva Markota 

机构地区：[1]Department of Endocrinology,Diabetes,Metabolic Diseases and Clinical Pharmacology,Clinical Hospital Dubrava,Zagreb 10000,Croatia [2]Department for Sport and Exercise Medicine,Faculty of Kinesiology University of Zagreb,Zagreb 10000,Croatia [3]Department of Oral Surgery,Clinical Hospital Dubrava,Zagreb 10000,Croatia [4]University of Zagreb School of Dental Medicine,Zagreb 10000,Croatia [5]Clinical Department of Pathology and Cytology,Clinical Hospital Dubrava,Zagreb 10000,Croatia

出　　处：《World Journal of Clinical Cases》2024年第7期1200-1204,共5页世界临床病例杂志

摘　　要：Hyperparathyroidism(HPT)is a condition in which one or more parathyroid glands produce increased levels of parathyroid hormone(PTH),causing disturbances in calcium homeostasis.Most commonly HPT presents with asymptomatic hypercalcemia but the clinical spectrum may include disturbances reflecting the combined effects of increased PTH secretion and hypercalcemia.Brown tumors are rare,benign,tumor-like bone lesions,occurring in 1.5%to 4.5%of patients with HPT,as a complication of an uncontrolled disease pathway,and are nowadays rarely seen in clinical practice.The tumor can appear either as a solitary or multifocal lesion and usually presents as an asymptomatic swelling or a painful exophytic mass.Furthermore,it can cause a pathological fracture or skeletal pain and be radiologically described as a lytic bone lesion.The diagnosis of a brown tumor in HPT is typically confirmed by assessing the levels of serum calcium,phosphorus,and PTH.Although when present,brown tumor is quite pathognomonic for HPT,the histologic finding often suggests a giant cell tumor,while clinical presentation might suggest other more frequent pathologies such as metastatic tumors.Treatment of brown tumors frequently focuses on managing the underlying HPT,which can often lead to regression and resolution of the lesion,without the need for surgical intervention.However,in refractory cases or when dealing with large symptomatic lesions,surgical treatment may be necessary.

关 键 词：Brown tumor HYPERPARATHYROIDISM Lytic bone lesions Giant cell tumor 

分 类 号：R733.3[医药卫生—肿瘤]