Investigating the causal associations between five anthropometric indicators and nonalcoholic fatty liver disease:Mendelian randomization study  

作　　者：Xian-Pei Xiao Yong-Jun Dai Yu Zhang Meng Yang Jian Xie Guo Chen Zheng-Jun Yang 

机构地区：[1]Department of Oncology,Luojiang District People's Hospital of Deyang City,Deyang 618000,Sichuan Province,China [2]Department of Orthopaedics,Luojiang District People's Hospital of Deyang City,Deyang 618000,Sichuan Province,China [3]Department of Infectious Diseases,Hospital of Chengdu University of Traditional Chinese Medical,Chengdu 610500,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2024年第7期1215-1226,共12页世界临床病例杂志

基　　金：Supported by Science and Technology Research Project of Sichuan Administration of Traditional Chinese Medicine,No.2023MS419.

摘　　要：BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been highlighted by accumulating evidence.AIM To evaluate the causal relationships between five anthropometric indicators and NAFLD employing Mendelian randomization(MR)design.METHODS The Anthropometric Consortium provided genetic exposure data for five anthropometric indicators,including hip circumference(HC),waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),and body fat percentage(BF).Genetic outcome data for NAFLD were obtained from the United Kingdom Biobank and FinnGen Consortium.Genome-wide significant single nucleotide polymorphisms were chosen as instrumental variables.Univariable MR(UVMR)and multivariable MR(MVMR)designs with analytical approaches,including inverse variance weighted(IVW),MR-Egger,weighted median(WM),and weighted mode methods,were used to assess the causal relationships between anthropometric indicators and NAFLD.RESULTS Causal relationships were revealed by UVMR,indicating that a higher risk of NAFLD was associated with a perunit increase in WC[IVW:odds ratio(OR)=2.67,95%CI:1.42-5.02,P=2.25×10^(−3)],and BF was causally associated with an increased risk of NAFLD(WM:OR=2.23,95%CI:1.07-4.66,P=0.033).The presence of causal effects of WC on the decreased risk of NAFLD was supported by MVMR after adjusting for BMI and smoking.However,no causal association between BF and NAFLD was observed.In addition,other causal relationships of HC,WHR(BMI adjusted),and BMI with the risk of NAFLD were not retained after FDR correction.CONCLUSION This study establishes a causal relationship,indicating that an increase in WC is associated with a higher risk of NAFLD.This demonstrates that a suitable decrease in WC is advantageous for preventing NAFLD.

关 键 词：Anthropometric indicator Waist circumference Nonalcoholic fatty liver disease Mendelian randomization Genetic variant 

分 类 号：R575.5[医药卫生—消化系统]