Sporadic gastrinoma with refractory benign esophageal stricture:A case report  

作　　者：Qian-Nan Chen Bing-Qing Bai Yan Xu Qiao Mei Xiao-Chang Liu 

机构地区：[1]Department of Gastroenterology,First Affiliated Hospital of Anhui Medical University,Hefei 230001,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2024年第7期1284-1289,共6页世界临床病例杂志

摘　　要：BACKGROUND Gastrinoma is characterized by an excessive release of gastrin,leading to hypersecretion of gastric acid,subsequently resulting in recurrent peptic ulcers,chronic diarrhea,and even esophageal strictures.This case report aims to improve awareness and facilitate early diagnosis and treatment of gastrinoma by presenting a rare case of gastrinoma with refractory benign esophageal stricture(RBES).Additionally,it highlights the persistent challenges that gastroenterologists encounter in managing RBES.CASE SUMMARY This case demonstrates a patient with gastrinoma who developed RBES and complete esophageal obstruction despite management with maximal acid suppressive therapy,multiple endoscopic bougie dilations and endoscopic incisional therapy(EIT).CONCLUSION It is essential to diagnose gastrinoma as early as possible,as inadequately controlled acid secretion over an extended period increases the risk of developing severe esophageal strictures.In patients with esophageal strictures causing complete luminal obstruction,blind reopening EIT presents challenges and carries a high risk of perforation.

关 键 词：GASTRINOMA Zollinger-Ellison syndrome Neuroendocrine neoplasm Chronic diarrhea Refractory benign esophageal stricture Case report 

分 类 号：R735.1[医药卫生—肿瘤]