Double plasma molecular adsorption system for Stevens–Johnson syndrome/toxic epidermal necrolysis:A case report  

作　　者：You-Wen Tan Li-Ping Liu Kai Zhang 

机构地区：[1]Department of Hepatology,The Third Hospital of Zhenjiang Affiliated Jiangsu University,Zhenjiang 212003,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2024年第7期1371-1377,共7页世界临床病例杂志

摘　　要：BACKGROUND Stevens–Johnson syndrome and toxic epidermal necrolysis(SJS/TEN)are very serious skin allergies,with an etiology related to infections and medication.Since the coronavirus disease 2019(COVID-19)pandemic,severe acute respiratory syndrome coronavirus-2 has also been considered to cause SJS/TEN.CASE SUMMARY We report the case of a woman in her thirties who took acetaminophen after contracting COVID-19.After 3 d of fever relief,she experienced high fever and presented with SJS/TEN symptoms,accompanied by intrahepatic cholestasis.Three days of corticosteroid treatment did not alleviate the skin damage;therefore,double plasma molecular adsorption system(DPMAS)therapy was initiated,with treatment intervals of 48 h.Her skin symptoms improved gradually and were resolved after seven DPMAS treatments.CONCLUSION DPMAS therapy is beneficial for abrogating SJS/TEN because plasma adsorption and perfusion techniques reduce the inflammatory mediators(e.g.,tumor necrosis factor-alpha and interleukin-10 and-12)speculated to be involved in the pathology of the skin conditions.

关 键 词：STEVENS-JOHNSON Toxic epidermal necrolysis COVID-19 Double plasma molecular adsorption system SARS-CoV-2 Case report 

分 类 号：R730.51[医药卫生—肿瘤] R575[医药卫生—临床医学]