Management of autoimmune hepatitis induced by hepatitis delta virus  

作　　者：Eleni Gigi Vasileios Lagopoulos Aris Liakos 

机构地区：[1]Hepatology Unit,The Second Internal Medicine Department,Aristotle University Medical School,Hippokrateio General Hospital,Thessaloniki 54642,Greece [2]Department of Surgical,AHEPA General Hospital of Thessaloniki,Thessaloniki 54636,Greece [3]Clinical Research and Evidence-Based Medicine Unit,Second Medical Department,Hippokratio General Hospital,Aristotle University Thessaloniki,Thessaloniki 54642,Greece

出　　处：《World Journal of Gastroenterology》2024年第8期799-805,共7页世界胃肠病学杂志（英文版）

摘　　要：Approximately 12-72 million people worldwide are co-infected with hepatitis B virus(HBV)and hepatitis delta virus(HDV).This concurrent infection can lead to several severe outcomes with hepatic disease,such as cirrhosis,fulminant hepatitis,and hepatocellular carcinoma,being the most common.Over the past few decades,a correlation between viral hepatitis and autoimmune diseases has been reported.Furthermore,autoantibodies have been detected in the serum of patients co-infected with HBV/HDV,and autoimmune features have been reported.However,to date,very few cases of clinically significant autoimmune hepatitis(AIH)have been reported in patients with HDV infection,mainly in those who have received treatment with pegylated interferon.Interestingly,there are some patients with HBV infection and AIH in whom HDV infection is unearthed after receiving treatment with immunosuppressants.Consequently,several questions remain unanswered with the challenge to distinguish whether it is autoimmune or“autoimmune-like”hepatitis being the most crucial.Second,it remains uncertain whether autoimmunity is induced by HBV or delta virus.Finally,we investigated whether the cause of AIH lies in the previous treatment of HDV with pegylated interferon.These pressing issues should be elucidated to clarify whether new antiviral treatments for HDV,such as Bulevirtide or immu-nosuppressive drugs,are more appropriate for the management of patients with HDV and AIH.

关 键 词：Autoimmune hepatitis Hepatitis delta virus Bulevirtide PREDNISOLONE 

分 类 号：R575[医药卫生—消化系统]