Cronkhite-Canada syndrome with esophagus involvement and sixyear follow-up:A case report  

作　　者：Yu-Chen Tang 

机构地区：[1]Department of Endocrinology,The First Affiliated Hospital of Ningbo University,Ningbo 315000,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2024年第8期984-990,共7页世界胃肠病学杂志（英文版）

基　　金：the Medical Health Science and Technology Project of Zhejiang Province,No.2022KY1109;the Natural Science Foundation of Ningbo,No.2022J204;Ningbo Key Clinical Specialty(Endocrinology),No.2022-B07.

摘　　要：BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare,noninherited disease characterized by gastrointestinal polyposis with diarrhea and ectodermal abnormalities.CCS polyps are distributed through the whole digestive tract,and they are common in the stomach and colon but very uncommon in the esophagus.CASE SUMMARY Here,we present a case of a 63-year-old man with skin hyperpigmentation accompanied by diarrhea,alopecia,and loss of his fingernails.Laboratory data indicated anemia,hypoalbuminemia,hypocalcemia,hypokalemia,and positive fecal occult blood.Endoscopy showed numerous polyps scattered throughout the digestive tract,including the esophagus.He was treated with nutritional support and glucocorticoids with remission of his symptoms.CONCLUSION Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical symptoms.Treatment should be individualized for each patient according to their therapy response.Surveillance endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.

关 键 词：Cronkhite-Canada syndrome Gastrointestinal polyposis Hormonal therapy Prognosis Case report 

分 类 号：R735.1[医药卫生—肿瘤]