Vonoprazan-amoxicillin dual regimen with Saccharomyces boulardii as a rescue therapy for Helicobacter pylori:Current perspectives and implications  

作　　者：Valerie Josephine Dirjayanto Jessica Audrey Daniel Martin Simadibrata 

机构地区：[1]Faculty of Medicine,Universitas Indonesia,Jakarta Pusat 10430,DKI Jakarta,Indonesia [2]Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,Minnesota 55905,United States [3]Nuffield Department of Population Health,University of Oxford,Oxford OX37LF,United Kingdom

出　　处：《World Journal of Gastroenterology》2024年第10期1280-1286,共7页世界胃肠病学杂志（英文版）

摘　　要：Yu et al’s study in the World Journal of Gastroenterology(2023)introduced a novel regimen of Vonoprazan-amoxicillin dual therapy combined with Saccharomyces boulardii(S.boulardii)for the rescue therapy against Helicobacter pylori(H.pylori),a pathogen responsible for peptic ulcers and gastric cancer.Vonoprazan is a potassium-competitive acid blocker renowned for its rapid and long-lasting acid suppression,which is minimally affected by mealtime.Compared to proton pump inhibitors,which bind irreversibly to cysteine residues in the H+/K+-ATPase pump,Vonoprazan competes with the K+ions,prevents the ions from binding to the pump and blocks acid secretion.Concerns with increasing antibiotic resistance,effects on the gut microbiota,patient compliance,and side effects have led to the advent of a dual regimen for H.pylori.Previous studies suggested that S.boulardii plays a role in stabilizing the gut barrier which improves H.pylori eradication rate.With an acceptable safety profile,the dual-adjunct regimen was effective regardless of prior treatment failure and antibiotic resistance profile,thereby strengthening the applicability in clinical settings.Nonetheless,S.boulardii comes in various formulations and dosages,warranting further exploration into the optimal dosage for supplementation in rescue therapy.Additionally,larger,randomized,double-blinded controlled trials are warranted to confirm these promising results.

关 键 词：Vonoprazan Saccharomyces boulardii Helicobacter pylori Rescue therapy Eradication rate 

分 类 号：R573[医药卫生—消化系统]