Unraveling the enigma:A comprehensive review of solid pseudopapillary tumor of the pancreas  

作　　者：Ye-Cheng Xu De-Liang Fu Feng Yang 

机构地区：[1]Department of Pancreatic Surgery,Pancreatic Disease Institute,Huashan Hospital,Fudan University,Shanghai 200040,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第3期614-629,共16页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Solid pseudopapillary tumor of the pancreas(SPTP)is a rare neoplasm predom-inantly observed in young females.Pathologically,CTNNB1 mutations,β-catenin nuclear accumulation,and subsequent Wnt-signaling pathway activation are the leading molecular features.Accurate preoperative diagnosis often relies on imaging techniques and endoscopic biopsies.Surgical resection remains the mainstay treatment.Risk models,such as the Fudan Prognostic Index,show promise as predictive tools for assessing the prognosis of SPTP.Establishing three types of metachronous liver metastasis can be beneficial in tailoring individu-alized treatment and follow-up strategies.Despite advancements,challenges persist in understanding its etiology,establishing standardized treatments for unresectable or metastatic diseases,and developing a widely recognized grading system.This comprehensive review aims to elucidate the enigma by consolidating current knowledge on the epidemiology,clinical presentation,pathology,molecular characteristics,diagnostic methods,treatment options,and prognostic factors.

关 键 词：PANCREAS Solid pseudopapillary tumor Β-CATENIN Endoscopic ultrasound Surgery RECURRENCE Liver metastasis Prognostic prediction 

分 类 号：R735.9[医药卫生—肿瘤]