涤痰汤联合抗生素治疗脑出血相关肺炎临床研究  

Clinical Study on Ditan Decoction Combined with Antibiotics for Cerebral Hemorrhage Associated Pneumonia

作　　者：费娜[1] 裘垚 张建松[1] FEI Na;QIU Yao;ZHANG Jiansong(Department of Critical Care Medicine,Shengzhou Hospital of Chinese Medicine,Shaoxing Zhejiang 312499,China)

机构地区：[1]嵊州市中医院重症医学科,浙江绍兴312499

出　　处：《新中医》2024年第3期7-10,共4页New Chinese Medicine

摘　　要：目的:观察涤痰汤联合抗生素治疗脑出血相关肺炎的临床疗效。方法:选取80例脑出血相关肺炎患者,按随机数字表法分为观察组和对照组各40例。对照组根据患者情况选择敏感抗生素治疗,观察组在对照组基础上给予涤痰汤治疗。2组均治疗7 d。评价2组临床疗效,比较2组体温、肺部影像学、白细胞计数(WBC)复常时间和肺部啰音消失时间,检测2组治疗前后超敏-C反应蛋白(hs-CRP)、降钙素原(PCT)及WBC水平,比较2组治疗前后临床肺部感染评分(CPIS)及神经功能缺损评分(NIHSS)评分。结果:观察组总有效率为95.00%,高于对照组77.50%(P<0.05)。观察组体温、肺部影像学、WBC复常时间和肺部啰音消失时间均短于对照组(P<0.05)。治疗后,2组hs-CRP、PCT、WBC水平均低于治疗前(P<0.05);且观察组hs-CRP、PCT、WBC水平均低于对照组(P<0.05)。治疗后,2组CPIS、NIHSS评分均低于治疗前(P<0.05),观察组CPIS、NIHSS评分均低于对照组(P<0.05)。结论:涤痰汤联合抗生素治疗脑出血相关肺炎患者,能缩短病程,恢复神经功能,降低炎症反应,提高临床疗效。Objective:To observe the curative effect of Ditan Decoction combined with antibiotics on cerebral hemorrhage associated pneumonia.Methods:A total of 80 cases of patients with cerebral hemorrhage associated pneumonia were selected and divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with sensitive antibiotics based on the patient's condition,and the observation group was treated with Ditan Decoction based on the treatment of the control group.Both groups were treated for 7 days.The clinical effects were evaluated between the two groups.The body temperature,pulmonary imaging,white blood cell count(WBC) normalization time,and lung rale disappearance time were compared between the two groups.The levels of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and WBC were detected before and after treatment in the two groups.The scores of Clinical Pulmonary Infection Score(CPIS) and National Institutes of Health Stroke Scale(NIHSS) were compared before and after treatment in the two groups.Results:The total effective rate was 95.00% in the observation group,higher than that of 77.50% in the control group(P<0.05).The body temperature,pulmonary imaging,WBC normalization time,and lung rale disappearance time in the observation group were lower or shorter than than those in the control group(P<0.05).After treatment,the levels of hs-CRP,PCT,and WBC in the two groups were lower than those before treatment(P<0.05);the levels of hs-CRP,PCT,and WBC in the observation group were lower than those in the control group(P<0.05).After treatment,the scores of CPIS and NIHSS in the two groups were lower than those before treatment(P<0.05),and the CPIS and NIHSS scores in the observation group were lower than those in the control group(P<0.05).Conclusion:Ditan Decoction combined with antibiotics for cerebral hemorrhage associated pneumonia can shorten the disease course,restore neurological function,reduce the levels o

关 键 词：脑出血相关肺炎 涤痰汤 抗生素 炎症因子 神经功能 临床肺部感染评分 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R563.1[医药卫生—临床医学]