滋阴养肝方超声雾化联合穴位注射治疗青春期儿童干眼症临床研究  

Clinical Study on Ultrasonic Atomization with Ziyin Yanggan Prescription Combined with Point Injection for Xerophthalmia in Adolescent Children

作　　者：许慧蕾 胡龙 彭烨 XU Huilei;HU Long;PENG Ye(Department of Ophthalmology,Zhejiang Lvcheng Cardiovascular Disease Hospital,Hangzhou Zhejiang 310000,China)

机构地区：[1]浙江绿城心血管病医院眼科,浙江杭州310000

出　　处：《新中医》2024年第3期110-114,共5页New Chinese Medicine

摘　　要：目的:观察滋阴养肝方超声雾化联合穴位注射治疗青春期儿童干眼症的临床疗效。方法:选择108例青春期干眼症患儿为研究对象,根据随机数字表法分为观察组与对照组各54例。对照组给予穴位注射治疗,观察组在对照组基础上给予滋阴养肝方超声雾化治疗。比较2组临床疗效,比较2组治疗前后中医证候评分,干眼症指标[眼表疾病指数(OSDI)量表评分、非侵入式泪膜破裂时间、非侵入式泪河高度、角膜荧光素染色评分],泪液炎症因子指标[白细胞介素-6 (IL-6)、白细胞介素-17 (IL-17)、肿瘤坏死因子-α (TNF-α)]。结果:治疗后观察组总有效率94.44%,高于对照组85.19%(P<0.05)。治疗后,2组眼睛干涩、眼部胀痛、视物模糊、头晕耳鸣等中医证候评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,2组OSDI量表评分、角膜荧光素染色评分均下降(P<0.05),非侵入式泪膜破裂时间均延长(P<0.05),非侵入式泪河高度均升高(P<0.05),且观察组OSDI量表评分、角膜荧光素染色评分低于对照组(P<0.05),非侵入式泪膜破裂时间长于对照组(P<0.05),非侵入式泪河高度高于对照组(P<0.05)。治疗后,2组泪液IL-6、IL-17、TNF-α水平均降低(P<0.05),且观察组低于对照组(P<0.05)。结论:滋阴养肝方超声雾化联合穴位注射治疗青春期儿童干眼症临床疗效显著,可缓解中医症状,促进患儿泪液分泌,延长泪膜破裂时间,改善角膜染色,降低泪液炎症指标。Objective:To observe the clinical effect of ultrasonic atomization with Ziyin Yanggan Prescription combined with point injection for xerophthalmia in adolescent children.Methods:A total of108 cases of adolescent children with xerophthalmia were selected as the study objects,and were divided into the observation group and the control group according to the random number table method,with 54cases in each group.The control group was treated with point injection,and the observation group was additionally treated with ultrasonic atomization with Ziyin Yanggan Prescription based on the treatment of the control group.The clinical effects were compared between the two groups;traditional Chinese medicine(TCM) syndrome scores,xerophthalmia indexes [Ocular Surface Disease Index(OSDI) scores,non-invasive tear break-up time,non-invasive tear meniscus height,corneal fluorescein staining scores],and tear inflammatory factor indexes [interleukin-6(IL-6),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)] were compared before and after treatment between the two groups.Results:After treatment,the total effective rate was 94.44% in the observation group,higher than that of 85.19% in the control group(P<0.05).After treatment,the scores of TCM syndromes including dry eyes,distending pain in eyes,blurred vision,dizziness and tinnitus in the two groups were decreased(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).After treatment,OSDI scores and corneal fluorescein staining scores in the two groups were decreased(P<0.05),non-invasive tear break-up time was shortened(P<0.05),and non-invasive tear meniscus height were increased(P<0.05);OSDI score and corneal fluorescein staining score in the observation group were lower than those in the control group(P<0.05),non-invasive tear break-up time was shorter than that in the control group(P<0.05),and the non-invasive tear meniscus height was higher than that in the control group(P<0.05).After treatment,the levels of IL-6,IL-17 and TNF-α i

关 键 词：干眼症 青春期儿童 滋阴养肝方 超声雾化 穴位注射 泪液炎症因子 

分 类 号：R777.34[医药卫生—眼科]