甜叶菊化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测  

Research progress on chemical composition and pharmacological effects of Stevia rebaudiana and its quality marker prediction analysis

作　　者：鲍玉龙 柳春燕 邵太丽 韩军 王国栋[1,2,3,4] BAO Yulong;LIU Chunyan;SHAO Taili;HAN Jun;WANG Guodong(Drug Research&Development Center,School of Pharmacy,Wannan Medical College,Wuhu 241002,China;Anhui Engineering Research Center for Polysaccharide Drugs,Wuhu 241002,China;Anhui Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicine in Southern,Wuhu 241002,China;Anhui Key Laboratory of Active Biological Macromolecules,Wuhu 241002,China;Anhui College of Traditional Chinese Medicine,Wuhu,241002,China;Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院药学院,药物研发中心,安徽芜湖241002 [2]安徽省多糖药物工程技术研究中心,安徽芜湖241002 [3]安徽省皖南地区植物药活性物质筛选与再评价工程实验室,安徽芜湖241002 [4]活性生物大分子研究安徽省重点实验室,安徽芜湖241002 [5]安徽中医药高等专科学校,安徽芜湖241002 [6]皖南医学院,新安医学与中医药现代化研究所,安徽芜湖241002

出　　处：《中草药》2024年第3期1014-1025,共12页Chinese Traditional and Herbal Drugs

基　　金：安徽省高校自然科学研究重大项目(KJ2021ZD0101,KJ2019ZD32);安徽省自然科学基金资助项目(1908085MH248);芜湖市科技项目(2022cg20);安徽省教育厅高校学科(专业)拔尖人才学术资助项目(gxbjZD2022043);大健康研究院新安医学与中医药现代化研究所专项资金(2023CXMMTCM011)。

摘　　要：甜叶菊Stevia rebaudiana是一种应用广泛的菊科植物,具有降血糖、抗肿瘤、抗氧化、抗炎、降血压、调血脂等多种药理作用,其化学成分主要包括二萜类、黄酮类、多酚类、多糖等。基于甜叶菊化学成分和药理作用的研究进展,从植物亲缘性和化学成分特有性、成分可测性、成分有效性及传统药性等方面对甜叶菊质量标志物(quality marker,Q-Marker)进行预测分析,初步预测甜菊苷、莱鲍迪苷A、莱鲍迪苷C、黄酮苷、绿原酸等可作为甜叶菊的主要Q-Marker,为完善甜叶菊质量评价体系提供参考。Tianyeju(Stevia rebaudiana)is a widely used plant of Asteraceae family,with various pharmacological effects such as hypoglycemic,antitumor,antioxidant,anti-inflammatory,hypotensive,and lipid-regulating effects,etc.Its chemical composition mainly includes diterpenes,flavonoids,polyphenols,and polysaccharides.Based on the research progress of chemical composition and pharmacological effects of S.rebaudiana,the quality marker(Q-Marker)of S.rebaudiana was predicted and analyzed from the aspects of plant affinity and chemical composition specificity,component measurability,component validity and traditional medicinal properties.The preliminary prediction was that stevioside,rebaudioside A,rebaudioside C,flavonoid glycosides and chlorogenic acid could be used as the main Q-Marker of S.rebaudiana,which would provide reference for improving the quality evaluation system of S.rebaudiana.

关 键 词：甜叶菊 二萜 黄酮 多糖 质量标志物 甜菊苷 莱鲍迪苷A 黄酮苷 绿原酸 杜尔可苷 

分 类 号：R285[医药卫生—中药学]