具核梭杆菌对结直肠癌诊疗作用的研究进展  

The role of Fusobacterium nucleatum in diagnosis and treatment of colorectal cancer:research progress

作　　者：闫玉琴 王伟 余繁荣 祁涛[2] 苏少晨[1,2] YAN Yuqin;WANG Wei;YU Fanrong;QI Tao;SU Shaochen(School of Stomatology,Lanzhou University,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]兰州大学口腔医学院,甘肃兰州730000 [2]兰州大学第一医院口腔科

出　　处：《中国微生态学杂志》2024年第1期110-114,共5页Chinese Journal of Microecology

基　　金：兰州市城关区科技计划项目(2019RCCX0033);兰州大学服务甘肃省经济社会发展专项研究项目(2019-FWZX-03);2022年陇原青年创新创业人才(团队)项目(2022LQTD57)。

摘　　要：口腔菌群作为人体的第二大微生物群,对人体健康具有非常重要的作用。具核梭杆菌是口腔中的常驻菌之一,与其他菌共同维持机体的稳态,现已被证实是结直肠癌最相关的菌属之一,参与结直肠癌的发生、发展以及预后。很多学者根据具核梭杆菌在结直肠癌中的致病机制,寻找以具核梭杆菌为靶点的对结直肠癌进行早期诊断和治疗的新方法。本文阐述了具核梭杆菌在结直肠癌中的致病机制,着重探讨其在结直肠癌的诊断和治疗中的潜在作用,以期为临床诊疗提供参考。As the second largest human microbial community,oral flora plays a very important role in human health.Fusobacterium nucleatum is one of the resident bacteria in oral cavity.It maintains the homeostasis of the body together with other bacteria.Fusobacterium nucleatum has been proved to be one of the genera most relevant to colorectal cancer.It is involved in the occurrence,development and prognosis of colorectal cancer.In recent years,it has attracted the attention of many scholars.According to the pathogenic mechanism of Fusobacterium nucleatum in colorectal cancer,a new method targeting Fusobacterium nucleatum for early diagnosis and treatment of colorectal cancer is sought.This paper expounds the pathogenic mechanism of Fusobacterium nucleatum in colorectal cancer,and focuses on the potential role of Fusobacterium nucleatum in the diagnosis and treatment of colorectal cancer,so as to provide reference for clinical diagnosis and treatment.

关 键 词：具核梭杆菌 结直肠癌 诊疗 

分 类 号：R735.3[医药卫生—肿瘤]