Recent advancements in the diagnosis and treatment of acral melanoma  

作　　者：Ahmad ALHASKAWI Sohaib Hasan Abdullah EZZI Yanzhao DONG Haiying ZHOU Zewei WANG Jingtian LAI Chengjun YAO Vishnu Goutham KOTA Mohamed Hasan Abdulla Hasan ABDULLA Hui LU 

机构地区：[1]Department of Orthopedics,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310003,China [2]Department of Orthopaedics,Third Xiangya Hospital,Central South University,Changsha,410013,China [3]Zhejiang University School of Medicine,Hangzhou,310058,China [4]Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare,Zhejiang University,Hangzhou,310058,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第2期106-122,共17页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：This work was supported by the Zhejiang Provincial Natural Science Foundation of China(No.LS21H060001);the Alibaba Youth Studio Project(No.ZJU-032);the Zhejiang Province Medical and Health Science and Technology Program(Nos.2022KY1455 and 2022RC136).The funding bodies had no role in the design of the study,in collection,analysis,and interpretation of data,or in drafting the manuscript.We thank Fatima ALALIWI and Ma LING for their invaluable support and encouragement.

摘　　要：Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late diagnosis.Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood tests.While surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the disease.Immune checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for AM.In this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease.

关 键 词：Acral melanoma Acral lentiginous melanoma Acral nevus Cutaneous malignant melanoma DERMOSCOPY Oncolytic virotherapy 

分 类 号：R739.5[医药卫生—肿瘤]