pH-sensitive KHA/CMC-Fe^(3+)@CS hydrogel loading and the drug release properties of riboflavin  

作　　者：Jie Song Xi Li Yuhua Niu Lijun Chen Zhiqiang Wei Yidan Li Youqian Wang 

机构地区：[1]Shaanxi University of Science&Technology,Xi'an,710021,China

出　　处：《Particuology》2024年第3期13-23,共11页颗粒学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant No.51803114);Shaanxi Province Key R&D Program(grant No.2022NY-195);Xi'an City Innovation Capability Strong Foundation Plan-Agricultural Technology R&D(grant No.21NYYF0025);Shaanxi Province Education Department Service Local Special Program Project(grant No.22jcO15);Shaanxi Province Key R&D Program(grant No.2020SF-411);Industry-University-Research Cooperation Project of Yulin Science and Technology Bureau(grant No.CXY-2020-086);National Key R&D Projects in 2021(grant No.2021YFC1808900).

摘　　要：To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

关 键 词：Potassium humate Hydrogel spheres PH-SENSITIVE Drugsustained-release Drug release model 

分 类 号：TQ427.26[化学工程]