Isolation and characterization of spike S2-specific monoclonal antibodies with reactivity to pan-coronaviruses  

作　　者：Yabin Hu Jun Chen Jing Yang Zhanpeng Liu Xiaoyue Zhang Qian Wu Lulu Liu Shishan Teng Rongzhang He Bo Liu Xingyu Zheng Rui Lu Dong Pan You Wang Liting Peng Hongying chen Yi-Ping Li Wenpei Liu Xiaowang Qu 

机构地区：[1]College of Basic Medical Sciences,Hengyang Medical School,University of South China&MOE Key Lab of Rare Pediatric Diseases,Hengyang,421001,China [2]Translational Medicine Institute,The First People's Hospital of Chenzhou,Hengyang Medical School,University of South China,Chenzhou,423000,China [3]College of Life Sciences,Northwest A&F University,Yangling,712100,China [4]Institute of Human Virology,Department of Pathogen Biology and Biosecurity,and Key Laboratory of Tropical Disease Control of Ministry of Education,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,510080,China [5]School of Public Health,University of South China,Hengyang,421001,China

出　　处：《Virologica Sinica》2024年第1期169-172,共4页中国病毒学（英文版）

基　　金：supported by the National Natural Science Foundation of China(82102365,92269115,32270996,82061138020);the Science and Technology Innovation Program of the Hunan Province of China(2022RC3079);the SC1-PHE-CORONAVIRUS-2020:Advancing Knowledge for the Clinical and Public Health Response to the 2019-nCoV Epidemic’from the European Commission(CORONADX,no.101003562,to Y-PL);Natural Science Foundation of the Hunan Province of China(2021JJ40006,2022JJ30095);Educational Commission of the Hunan Province of China(21A0529);the Clinical Medical Innovation Technology Guide Project of the Hunan Province(2021SK50304,2021SK50306 and 2021SK50312);the Scientific Research Innovation Project of Graduate of Hunan Province(CX20221024);the Scientific Research Innovation Project of Graduate of University of South China(213YXC019);approved by the Institutional Ethical Review Board of The Central Hospital of Shaoyang,Hunan Province,China(V.1.0,20200301);The First People's Hospital of Chenzhou,Hunan Province,China(V.3.0,2021001)。

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),theseventh coronavirus known to jump from intermediate hosts to humans,has resulted in a worldwide pandemic and caused immense economicdamage(Tan et al.,2020;Zhu et al.,2020).It is believed that coronavirus spillover may occur again in the future.Human exposure to a bat coro-navirus has been serologically confimed in a rural area of China,indi-cating that the coronavirus spillover occurred,although the origin andfrequency of spillovers are unclear(Wang et al.,2018).

关 键 词：MONOCLONAL acute 

分 类 号：R392-33[医药卫生—免疫学]