健脾扶正方联合SOX新辅助化疗对胃癌根治术患者肿瘤标志物水平及免疫功能的影响  

The Effect of Jianpi Fuzheng Recipe Combined with SOX Neoadjuvant Chemotherapy on the Levels of Tumor Markers and Immune Function in Patients Undergoing Radical Gastrectomy for Gastric Cancer

作　　者：杨建伟[1] 蔡灵静 陈雅珠 YANG Jianwei;CAI Lingjing;CHEN Yazhu(Jian'ou Integrated Traditional Chinese and Western Medicine Hospital,Nanping Fujian 353100,China)

机构地区：[1]建瓯市中西医结合医院,福建南平353100

出　　处：《药品评价》2023年第11期1357-1360,共4页Drug Evaluation

摘　　要：目的探析健脾扶正方联合奥沙利铂+替吉奥(SOX)新辅助化疗对胃癌根治术患者肿瘤标志物水平及免疫功能的影响。方法采用前瞻性研究方法,纳入2020年4月至2022年4月于建瓯市中西医结合医院行胃癌根治术的胃癌患者88例,随机数字表法分为两组,各44例。对照组给予SOX新辅助化疗治疗,观察在对照组基础上加用健脾扶正方治疗。比较两组控制率,肿瘤标志物[血清癌胚抗原(CEA)、糖类抗原199(CA199),糖类抗原125(CA125)],免疫功能[CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]以及不良反应。结果观察组控制率高于对照组,差异有统计学意义(P<0.05)。经6周治疗,两组CEA、CA199以及CA125均低于治疗前,观察组各指标水平变化更明显(P<0.05);两组CD4^(+)、CD4^(+)/CD8^(+)均高于^(+)治疗前,CD8低于治疗前,且观察组各指标变化更为显著(P<0.05)。两组患者不良反应对比,差异不明显(P>0.05)。结论健脾扶正方联合SOX新辅助化疗对胃癌根治术患者疗效显著,可有效改善肿瘤标志物水平,强化免疫系统。Objective To explore the effect of jianpi fuzheng recipe combined with oxaliplatin and tegafur(SOX)neoadjuvant chemotherapy on tumor marker levels and immune function in patients undergoing radical gastrectomy for gastric cancer.Methods A prospective study was conducted,including 88 gastric cancer patients who underwent radical gastrectomy at the Jian'ou Integrated Traditional Chinese and Western Medicine Hospital from April 2020 to April 2022.They were randomly divided into two groups,with 44 patients in each group;the control group was treated with SOX neoadjuvant chemotherapy and the observation group was treated with jianpi fuzheng recipe based on the control group.Compare the control rates,tumor markers[serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),and carbohydrate antigen 125(CA125)],immune function[CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)],and adverse reactions between the two groups.Results The control rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After 6 weeks of treatment,CA199,and CA125 in both groups were lower than before treatment,and the levels of various indicators in the observation group showed more significant changes(P<0.05);CD4^(+)and CD4^(+)/CD8^(+)in both groups were higher than before treatment,while CD8^(+)was lower than before treatment,and the changes in various indicators in the observation group were more significant(P<0.05);there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of jianpi fuzheng recipe and SOX neoadjuvant chemotherapy has a significant therapeutic effect on patients undergoing radical gastrectomy for gastric cancer,which can effectively improve the levels of tumor markers and strengthen the immune system.

关 键 词：胃癌根治术 健脾扶正方 肿瘤标志物 免疫功能 血清癌胚抗原 

分 类 号：R735.2[医药卫生—肿瘤]