T淋巴细胞免疫治疗进展  

Progress of T Lymphocyte Immunotherapy

作　　者：李轶甫 孙雪松 麦海强[1,2] LI Yifu;SUN Xuesong;MAI Haiqiang(State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China;Department of Nasopharyngeal Carcinoma,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,广东省鼻咽癌诊治研究重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510060 [2]中山大学肿瘤防治中心鼻咽癌科,广州510060

出　　处：《中国细胞生物学学报》2023年第12期1864-1873,共10页Chinese Journal of Cell Biology

摘　　要：作为肿瘤微环境的重要组成部分,T淋巴细胞在肿瘤的发生、发展中发挥着极其重要的作用,被称为人体内的特种兵。但由于免疫逃逸机制的存在,癌细胞通常会伪装自己,让T细胞无法被识别出,以此躲避人体免疫系统的攻击,那么到底要如何唤醒体内的T细胞来歼灭癌细胞,成为当下肿瘤研究的热点。在过去的几十年,从基础研究到临床应用,诞生了多种基于T淋巴细胞免疫反应的新型抗肿瘤治疗方法,主要有以下三种类型:细胞毒性T淋巴细胞治疗、嵌合抗原受体T细胞治疗以及T细胞受体工程化T细胞治疗。该文简要综述了这三种T细胞免疫治疗的机制、技术与临床应用。As an important component of the tumor microenvironment,T lymphocytes play an extremely important role in the occurrence and development of tumors.However,due to the existence of immune escape mechanisms,cancer cells often disguise themselves,making it difficult for T cells to recognize them,so that they can evade attacks from the human immune system.Therefore,how to awaken T cells in the body to eliminate cancer cells has become a hot topic nowadays.In the past few decades,various new anti-tumor treatment methods based on T lymphocyte immune response have emerged in the field of basic research and clinical application.There are mainly three types of T cell immunotherapy:cytotoxic T lymphocyte therapy,chimeric antigen receptor T cell therapy,and T-cell receptor engineered T cell therapy.This article briefly reviews the mechanisms,techniques,and clinical applications of these three types of T cell immunotherapy.

关 键 词：免疫治疗 细胞毒性T淋巴细胞 嵌合抗原受体T细胞 T细胞受体工程化T细胞 

分 类 号：R730.51[医药卫生—肿瘤]