肝纤维化的早期血清标志物研究进展  

Advances in the study on early serum markers of liver fibrosis

作　　者：魏莎 陈晰 章臻翊 邓秀娟 张镓 吴浪 WEI Sha;CHEN Xi;ZHANG Zhenyi;DENG Xiujuan;ZHANG Jia;WU Lang(The Third Hospital of Changsha,Changsha,Hunan 410035,China;Hunan Provincial Corps Hospital,Chinese People’s Armed Police Forces,Changsha,Hunan 410006,China)

机构地区：[1]长沙市第三医院,湖南长沙410035 [2]中国人民武警部队湖南省总队医院,湖南长沙410006

出　　处：《实用预防医学》2024年第2期252-256,F0003,共6页Practical Preventive Medicine

基　　金：湖南省临床医疗技术创新引导项目(2020SK52902)。

摘　　要：肝纤维化是慢性肝病的一种病理性修复反应,其特征是细胞外基质的过度积累和重组。肝活检是肝脏纤维化诊断的金标准。由于该方法的各种局限性,包括患者损伤和取样错误的风险,因此使用肝纤维化的非侵入性血清标志物显得尤为重要。随着深入研究的进行,一些新出现的生物学标志物为临床早期预测肝纤维化的严重程度,评估治疗效果,改善预后及寻找新的治疗靶点提供了新的线索。Liver fibrosis is a pathological repair response to chronic liver disease,amd is characterized by the overaccumulation and reorganization of extracellular matrix.Liver biopsy is the gold standard for liver fibrosis determination.The use of non-invasive serum markers of liver fibrosis is particularly important due to the various limitations of this method,including patient injury and the risk of sampling errors.With intensive researches,some emerging biological markers are providing new clues to early predicting the severity of liver fibrosis in the clinical setting,assessing the effectiveness of treatment,improving the prognosis and finding out new therapeutic targets.

关 键 词：血清标记物 肝纤维化 细胞外基质 甘胆酸 新表位 

分 类 号：R575.2[医药卫生—消化系统]