Exploring stool-based microrna-92a as a potential biomarker for colorectal cancer diagnosis  

作　　者：Ao Jian Yue Jie Man Luo Rong-Bin Liu 

机构地区：[1]Department of General Surgery,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou 510700,China [2]Department of Ultrasound,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China [3]GuangDong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-sen Memorial Hospital Sun Yat-sen University,Guangzhou 510120,China

出　　处：《Cancer Advances》2023年第24期1-7,共7页TMR肿瘤进展

基　　金：This study was supported by the National Natural Science Foundation of China(Grant No.82202907 to Rong-Bin Liu).

摘　　要：Background:Stool-based molecular markers have shown potential as a strategy for colorectal cancer(CRC)screening.This study aimed to evaluate the feasibility of using microRNA-92a expression as a biomarker for CRC in stool samples.Methods:The level of microRNA-92a was measured in stool samples from 210 CRC patients,29 patients with advanced adenomas,15 patients with other cancers,and 101 healthy controls,using real-time quantitative polymerase chain reaction.Receiver operating characteristic curves were used to evaluate sensitivity and specificity.Results:MicroRNA-92a expression was positive in 70.1%of CRC patients,44.8%of advanced adenomas patients,and 36.6%of healthy controls,using a cut-off value of 31.5.The corresponding sensitivity and specificity for discriminating CRC from advanced adenomas were 66.9%and 63.4%,respectively.Moreover,stool-based microRNA-92a expression was better at detecting CRC cancers in the distal colon(sensitivity 82.1%)than the proximal colon(sensitivity 67.9%).There were no significant differences in clinical stage of CRC when comparing AUCs of each parameter(P>0.05).Conclusion:These findings suggest that microRNA-92a expression in stool samples could serve as a promising non-invasive biomarker for CRC detection.

关 键 词：colorectal cancer advanced adenomas microRNA-92a stool-based biomarkers 

分 类 号：R73[医药卫生—肿瘤]