肺癌组织TCF21、ANGPT1、SSTR2表达及联合检测对胸腔镜根治术后复发转移预测价值探究  

Expression of TCF21,ANGPT1 and SSTR2 in lung cancer and their combined detection value in predicting recurrence and metastasis after thoracoscopic radical surgery

作　　者：于卫民[1] 刘传[2] 王嵘 李娜[4] YU Wei-min;LIU Chuan;WANG Rong;LI Na(Department of Thoracic Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 451450,China;Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 451450,China;Kaifeng Traditional Chinese Medicine Hospital,Kaifeng,Henan 475000,China;Department of Gynecology,The First Affiliated Hospital of Zhengzhou University Zhengzhou 451450,China)

机构地区：[1]郑州大学第一附属医院胸外科,郑州451450 [2]郑州大学第一附属医院呼吸与危重症医学科,郑州451450 [3]开封市中医院,河南开封475000 [4]郑州大学第一附属医院妇科,郑州451450

出　　处：《医药论坛杂志》2024年第1期44-48,共5页Journal of Medical Forum

摘　　要：目的探讨肺癌组织转录因子21(TCF21)、血管生成素1(ANGPT1)、生长抑素受体2(SSTR2)表达及联合检测对胸腔镜根治术后复发转移预测价值。方法选取2020年6月至2022年6月于郑州大学第一附属医院进行胸腔镜根治术治疗的265例(均完成随访)肺癌患者为研究对象,收集术后肺癌组织及相对应的癌旁组织,根据术后6个月复发转移情况分为复发转移组(26例)和未复发转移组(239例)。比较肺癌组织和癌旁组织、不同病理学参数肺癌患者癌组织TCF21、ANGPT1、SSTR2表达水平,分析癌组织TCF21、ANGPT1、SSTR2表达水平与病理学参数及术后复发转移相关性,受试者工作特征曲线(ROC)分析癌组织TCF21、ANGPT1、SSTR2表达水平联合检测对肺癌患者术后复发转移的预测价值。结果肺癌组织中TCF21、ANGPT1表达水平低于癌旁组织,SSTR2表达水平高于癌旁组织(P<0.05);复发转移组肺癌组织TCF21、ANGPT1表达水平低于未复发转移组,SSTR2表达水平高于未复发转移组(P<0.05);不同病理学参数肺癌患者癌组织TCF21、ANGPT1表达水平比较:Ⅰ+Ⅱ期高于Ⅲ+Ⅳ期,高+中分化高于低分化,无淋巴结转移高于有淋巴结转移(P<0.05);不同病理学参数肺癌患者癌组织SSTR2表达水平比较:Ⅰ+Ⅱ期低于Ⅲ+Ⅳ期,高+中分化低于低分化,无淋巴结转移低于有淋巴结转移(P<0.05);TNM分期、淋巴结转移、复发转移与肺癌组织中TCF21、ANGPT1表达水平呈正相关,与SSTR2表达水平呈负相关(P<0.05);ROC曲线分析结果显示,肺癌组织中TCF21、ANGPT1、SSTR2表达水平联合预测肺癌患者胸腔镜根治术后复发转移的曲线下面积(AUC)为0.803,最佳预测敏感度、特异度分别为92.31%、68.20%,高于单一指标预测(P<0.05)。结论TCF21、ANGPT1、SSTR2参与肺癌发生发展,且在预测肺癌患者腔镜根治术后复发转移风险方面具有较高效能。Objective To investigate the expression and combined detection of transcription factor 21(TCF21),AN⁃GPT1(ANGPT1)and somatostatin receptor 2(SSTR2)in lung cancer tissues in the prediction of recurrence and metas⁃tasis after thoracoscopic radical surgery.Methods A total of 265 patients with lung cancer who underwent thoracoscopic radical surgery in our hospital from June 2020 to June 2022(all completed follow-up)were selected as research ob⁃jects.Postoperative lung cancer tissues and corresponding adjacent tissues were collected and divided into a recurrence and metastasis group(26 cases)and a non-recurrence and metastasis group(239 cases)according to the recurrence and metastasis situation 6 months after surgery.The expression levels of TCF21,ANGPT1 and SSTR2 in lung cancer tis⁃sues and adjacent tissues and different pathological parameters of lung cancer patients were compared,and the correla⁃tion between the expression levels of TCF21,ANGPT1 and SSTR2 in cancer tissues and pathological parameters as well as postoperative recurrence and metastasis was analyzed.Receiver operating characteristic curve(ROC)analysis of the combined detection of TCF21,ANGPT1 and SSTR2 expression levels in cancer tissue in the prediction of postoperative recurrence and metastasis of lung cancer patients.Results The expression levels of TCF21 and ANGPT1 in lung cancer tissues were lower than those in paracancer tissues,and the expression levels of SSTR2 were higher than those in para⁃cancer tissues(P<0.05).The expression levels of TCF21 and ANGPT1 in relapsed and metastatic group were lower than those in non-relapsed and metastatic group,and the expression levels of SSTR2 were higher than those in non-relapsed and metastatic group(P<0.05).The expression levels of TCF21 and ANGPT1 in lung cancer patients with different pathological parameters were higher in stageⅠ+Ⅱthan that in stageⅢ+Ⅳ,higher in stage+medium dif⁃ferentiation than that in stage low differentiation,higher in no lymph node metastasis than that in lymp

关 键 词：肺癌 胸腔镜根治术 复发转移 转录因子21 血管生成素1 生长抑素受体2 

分 类 号：R734[医药卫生—肿瘤]