机构地区:[1]河南省人民医院日间外科病房,郑州450003
出 处:《医药论坛杂志》2024年第1期79-82,86,共5页Journal of Medical Forum
基 金:河南省科技厅科技攻关项目(202102310100)。
摘 要:目的研究三维适形放疗联合恩扎卢胺对激素抵抗型晚期前列腺癌患者的治疗价值。方法选取60例于2020年6月至2022年2月来河南省人民医院就诊的晚期前列腺癌患者,将其随机分为联合组和对照组,两组各30例。其中对照组给予恩扎卢胺治疗,联合组则在此基础上联合给予三维适形放射治疗。比较两组患者治疗前及治疗后的肿瘤标志物[前列腺特异性抗原(PSA)、早期前列腺癌抗原-2(EPCA-2)]、症状评分[国际前列腺症状评分(IPSS)]和生活质量[前列腺癌患者生活质量量表(FACT-P)]及治疗3个月后的临床疗效、两组患者的毒副作用及随访1年患者的生存状况。结果治疗3个月联合组与对照组相比较,其临床疗效明显更好,客观缓解率明显更高(P<0.05)。两组患者治疗3个月与治疗前相比较,其各项肿瘤标志物水平、IPSS和FACT-P评分均降低且差异显著(P<0.05)。治疗3个月,联合组与对照组相比较,不良反应发生差异无统计学意义(P>0.05)。联合组患者的生存率较对照组改善且差异有统计学意义(P<0.05)。结论三维适形放疗联合恩扎卢胺用于治疗激素抵抗型晚期前列腺癌患者,可改善其临床疗效的同时控制血清肿瘤标志物水平,缓解临床症状从而改善患者生活质量,安全性尚可,有利于延长患者无进展生存期,改善疾病预后。Objective To study the therapeutic value of three-dimensional conformal radiotherapy combined with enzalu⁃tamide in patients with hormone-resistant advanced prostate cancer.Methods Sixty patients with advanced prostate cancer who came to our hospital from June 2020 to February 2022 were selected.They were randomly divided into a combi⁃nation group and a control group,with 30 cases in each group.The control group was given enzalutamide,and the combi⁃nation group was given three-dimensional conformal radiation therapy on this basis.The clinical efficacy of the two groups after 3 months of treatment was compared,and the tumor markers[prostate-specific antigen(PSA),early prostate canc⁃er antigen-2(EPCA-2)],symptom scores before and after treatment between the two groups were compared and ana⁃lyzed.[International Prostate Symptom Score(IPSS)]and quality of life[Life Quality Scale for Patients with Prostate Cancer(FACT-P)];The incidence of toxic and side effects in the two groups during the treatment cycle was compared,and the patients were followed up for 1 year to observe the survival of the patients and do survival curve analysis.Results Compared with the control group after three months of treatment,the patients in the combination group had sig⁃nificantly better clinical curative effect,and the objective remission rate was significantly higher(P<0.05).Compared with that before treatment,the levels of various tumor markers,IPSS and FACT-P scores in the two groups were decreased af⁃ter three months of treatment,and the difference was significant(P<0.05).The combined group was lower than that of the control group at the same time,and the difference was statistically significant(P<0.05).There was no significant difference in the toxic and side effects between the two groups within 3 months of treatment(P>0.05).The survival time of patients in the combined group was longer than that in the control group and the difference was statistically significant(P<0.05).Conclusion Three-dimensional conformal radiothe
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