新生血管性年龄相关性黄斑变性相关的视网膜下纤维化的研究进展  

Research progress of subretinal fibrosis associated with neovascular age-related macular degeneration

作　　者：李璐希 张鹏[1] Li Luxi;Zhang Peng(Department of Ophthalmology,Affiliated Hospital of Northwest University,Xi′an No.3 Hospital,Xi′an 710018,China)

机构地区：[1]西北大学附属医院西安市第三医院眼科,西安710018

出　　处：《中华眼底病杂志》2024年第3期239-242,共4页Chinese Journal of Ocular Fundus Diseases

摘　　要：新生血管性老年性黄斑变性(nAMD)导致的严重视力损害与黄斑新生血管(MNV)的侵袭及视网膜下纤维化(SF)有关。过度的SF可导致视网膜下瘢痕形成,使光感受器、视网膜色素上皮和脉络膜组织发生不可逆性损害,使得nAMD患者出现永久视力障碍。SF发生机制复杂,涉及组织损伤后修复、炎症等诸多病理学过程,与之相关的信号通路及细胞因子。目前对于SF的实验性治疗仅针对单个细胞因子的抑制。及时有效抑制MNV的生成及进展,早期识别SF发生的危险因素,对改善nAMD患者的预后至关重要。The severe visual impairment caused by neovascular age-related macular degeneration(nAMD)is associated with macular neovascularization(MNV)invasion and subretinal fibrosis(SF).Excessive SF can lead to subretinal scarring,irreversible damage to photoreceptors,retinal pigment epithelium,and choroid tissue,resulting in permanent visual impairment in nAMD patients.The pathogenesis of SF is complex,involving many pathological processes such as tissue repair after injury,inflammation,and related signaling pathways and cytokine complex.Current experimental treatments for SF only target inhibition of a single cytokine.Timely and effective inhibition of the formation and progression of MNV and early identification of risk factors for SF are crucial to improving the prognosis of nAMD patients.

关 键 词：年龄相关性黄斑变性 视网膜下纤维化 脉络膜新生血管 黄斑新生血管 综述 

分 类 号：R774.5[医药卫生—眼科]