年龄相关听力损失与阿尔茨海默病相关性的两样本孟德尔随机化分析  

Two-sample Mendelian randomized analysis of the correlation betweenage-related hearing loss and Alzheimer’s disease

作　　者：吴素素 胡芳晓 黄巧艺 常佳欢 刘南阳 曹宇[4] 裴卉[4] 李浩 WU Su-su;HU Fang-xiao;HUANG Qiao-yi;CHANG Jia-huan;LIU Nan-yang;CAO Yu;PEI Hui;LI Hao(Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院望京医院,北京100102 [3]山东中医药大学第一临床医学院 [4]中国中医科学院西苑医院老年病科,北京100091 [5]山东中医药大学第二附属医院风湿免疫科

出　　处：《现代预防医学》2024年第5期769-775,共7页Modern Preventive Medicine

基　　金：国家重点研发计划“中医药现代化”重点专项(2022YFC3501400);医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者(国中医药办人教函[2019]62号);中央级公益性科研院所基本科研业务费专项资金资助项目(ZZ15-XY-PT-02)。

摘　　要：目的本研究通过双样本孟德尔随机化分析探讨年龄相关性听力损失与阿尔茨海默病之间的因果关系。方法采用逆方差加权、MR-Egger回归、加权中位数、简单模型和加权模型五种方法来评估年龄相关性听力损失与阿尔茨海默病风险之间的关系,采用敏感性分析(多效性、异质性和留一性检验)来评估结果的稳健性。结果统计结果显示与年龄相关的听力损失和阿尔茨海默病之间未见因果关联(逆方差加权法:OR=1.0526,95%CI:0.7155~1.5485;MR-Egger:OR=1.1347,95%CI:0.2123~6.0660;加权中位数法:OR=0.8908,95%CI:0.5281~1.5025;简单模型法:OR=0.7157,95%CI:0.2505~2.0445;加权模型法:OR=0.7470,95%CI:0.3153~1.7698),这些结果与阿尔茨海默病代理数据相一致(逆方差加权法:OR=0.9560,95%CI:0.9008~1.0146;MR-Egger:OR=0.9887,95%CI:0.7729~1.2647;加权中位数法:OR=0.9487,95%CI:0.8752~1.0283;简单模型法:OR=0.9597,95%CI:0.8147~1.1305;加权模型法:OR=0.9632,95%CI:0.8298~1.1179),敏感性分析显示没有显著的异质性或多效性,表明结果是稳健的。结论没有证据表明与年龄相关的听力损失与患阿尔茨海默病的风险增加有关。Objective To explore the causal relationship between age-related hearing loss and Alzheimer’s disease through two-sample Mendelian randomized analysis.Methods Inverse variance weighted,MR-Egger regression,weighted median,simple model,and weighted model were used to evaluate the relationship between age-related hearing loss and the risk of Alzheimer’s disease.Sensitivity analysis(pleiotropy,heterogeneity,and leave-one-out test)was used to evaluate the robustness of the results.Results Statistical results showed that there was no causal association between age-related hearing loss and Alzheimer’s disease(inverse variance weighting method:OR=1.0526,95%CI:0.7155-1.5485;MR-Egger:OR=1.1347,95%CI:0.2123-6.0660;weighted median method:OR=0.8908,95%CI:0.5281-1.5025;simple model method:OR=0.7157,95%CI:0.2505-2.0445;weighted model method:OR=0.7470,95%CI:0.3153-1.7698).These results were consistent with that of Alzheimer’s disease proxy cases(inverse variance weighting method:OR=0.9560,95%CI:0.9008-1.0146;MR-Egger:OR=0.9887,95%CI:0.7729-1.2647;weighted median method:OR=0.9487,95%CI:0.8752-1.0283;simple model method:OR=0.9597,95%CI:0.8147-1.1305;Weighted model method:OR=0.9632,95%CI:0.8298-1.1179).Sensitivity analysis showed that there was no significant heterogeneity or pleiotropy,indicating that the results were robust.Conclusion There is no evidence that age-related hearing loss is associated with an increased risk of Alzheimer’s disease.

关 键 词：孟德尔随机化分析 与年龄有关的听力损失 阿尔茨海默病 因果关系 危险因素 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R764[医药卫生—临床医学]