血清TNF-α水平监测及微生物形态学检验在泌尿系统感染预防与诊治中的临床价值分析  

Serum TNF-αanalysis of clinical value of level monitoring and microbial morphology test in prevention,diagnosis and treatment of urinary tract infection

作　　者：段雨函 郭浩 Duan Yuhan;Guo Hao(Clinical Laboratory Center,Hubei Enshi Central Hospital,Enshi 445000,China;Department of Canter,Hubei Enshi Central Hospital,Enshi 445000,China)

机构地区：[1]湖北省恩施州中心医院临床检验中心,恩施445000 [2]湖北省恩施州中心医院肿瘤科,恩施445000

出　　处：《国际泌尿系统杂志》2024年第2期265-268,共4页International Journal of Urology and Nephrology

摘　　要：目的探讨血清肿瘤坏死因子-α(TNF-α)水平监测及微生物形态学检验在泌尿系统感染预防与诊治中的临床价值。方法选取2017年6月至2020年8月本院收治的114例泌尿系统感染患者设为研究组,选取同期体检的86例健康人作为对照组,观察两组患者的血清TNF-α水平。根据不同检验方式将研究组分为常规检验组(57例)和微生物检验组(57例),分析比较两组患者的临床诊断准确率。结果研究组的血清TNF-α水平高于对照组,差异有统计学意义(P<0.05)。微生物检验组的确诊率高于常规检验组,差异有统计学意义[91.23%(52/57)vs.75.44%(43/57),P=0.023]。治疗14 d后,微生物检验组的重度及中度感染患者少于常规检验组,轻度感染患者多于常规检验组,差异均有统计学意义(均P<0.05)。泌尿系统感染和血清TNF-α水平呈正相关(r=0.271,P=0.012)。结论血清TNF-α水平是泌尿系统感染患者的潜在诊断标志,而微生物形态学检验对于泌尿系统感染患者也是可行的,能有效判断病原菌感染类型,对临床防治及诊治作用较大。Objective To investigate the serum tumor necrosis factor-alpha(TNF-α),and to analyze the clinical value of level monitoring and microbial morphology test in the prevention and treatment of urinary tract infection.Methods A total of 114 patients with urinary system infection admitted to our hospital from June 2017 to August 2020 were selected as the study group,and 86 healthy people who underwent physical examination during the same period were selected as the control group.Serum TNF-αlevels of the two groups of patients were observed.Then the study group was divided into routine test group(57 cases)and microbiological test group(57 cases)according to the test method,and the clinical diagnosis accuracy of the two groups was analyzed and compared.Results The serum TNF-αlevel of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The diagnosis rate of the microbiological test group was higher than that of the canventional test group,and the difference was statistically significant[91.23%(52/57)vs.75.44%(43/57),P=0.023].After 14 days of treatment,the patients with severe and moderate infection in the microbiological test group were less than those in the conventional test group,and the patients with mild infection were more than those in the conventional test group,with statistical significance(all P<0.05).Urinary system infection was positively correlated with serum TNF-αlevels(r=0.271,P=0.012).Conclusions Serum TNF-αlevel is a potential diagnostic marker for patients with urinary system infection,and microbial morphology test is also feasible for patients with urinary system infection,which can effectively determine the type of pathogenic bacteria infection,and has a great role in clinical prevention and treatment.

关 键 词：肿瘤坏死因子Α 尿路感染 微生物学检验 

分 类 号：R446.5[医药卫生—诊断学] R691.3[医药卫生—临床医学]