Mo@PANI-catalyzed oxidative deoximation reaction  

作　　者：Yiyang Zhang Wen Li Zuofeng Hu Xiaobi Jing Lei Yu 

机构地区：[1]School of Mechanical Engineering,Yangzhou University,Yangzhou 225127,China [2]School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China [3]Yangzhou Yangzi Auto Interior & Exterior Co.,Ltd.,Yangzhou 225119,China

出　　处：《Chinese Chemical Letters》2024年第2期407-410,共4页中国化学快报（英文版）

基　　金：Priority Academic Program Development of Jiangsu Higher Education Institutions for support;financially supported by the fund of the joint-laboratory of Shanghai Dingya Pharmaceutical Chemical Technology Co.,Ltd.with Yangzhou University(No.2022-2027).

摘　　要：Deoximation is an important transformation in synthetic industry.It can be employed in protection,characterization and purification of the carbonyls,and in the synthesis of ketones from non-carbonyl molecules.In the field,oxidative deoximation reaction can utilize the driving force caused by the oxidation process so that the reaction can occur under relatively mild conditions.Recently,we designed and prepared polyaniline-supported molybdenum(Mo@PANI)just by immersing PANI into the EtOH/H_(2)O solution of MoCl_(5).The material was successfully applied as the efficient catalyst for oxidative deoximation reactions,which were performed in ethanol using H_(2)O_(2)as the clean oxidant.The substrate scope of the reaction was wide.It could be applied on heterocycle-containing substrates,making this protocol preferable for pharmaceutical intermediate synthesis.Since Mo is a necessary trace element for both animals and plants,this method is environment-friendly and is suitable for large-scale preparation.This work as the first example of Mo-catalyzed oxidative deoximation reaction may inspire novel ideas for both catalyst design and synthetic process development.

关 键 词：MOLYBDENUM POLYANILINE Oxidation DEOXIMATION CARBONYL 

分 类 号：O621.251[理学—有机化学]