FNAC联合FNA-Tg检测在甲状腺乳头状癌颈侧区淋巴结转移中的诊断价值  

Diagnostic value of FNAC combined with FNA-Tg detection in cervical lymph node metastasis of papillary thyroid carcinoma

作　　者：孟岩[1] 王英 许崇文[3] 刘俊松[3] 白艳霞[3] 邵渊[3] 李宏慧[3] MENG Yan;WANG Ying;XU Chongwen;LIU Junsong;BAI Yanxia;SHAO Yuan;LI Honghui(Otolaryngology Head and Neck Surgery Department,Honghui Hospital Affiliated to Xi'an Jiaotong University,Xi'an 710054;Radiology Department,Xi'an Jiaotong University Hospital,Xi'an 710049;Otolaryngology Head and Neck Surgery Department,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学附属红会医院耳鼻咽喉头颈外科,陕西西安710054 [2]西安交通大学医院放射科,陕西西安710049 [3]西安交通大学第一附属医院耳鼻咽喉头颈外科,陕西西安710061

出　　处：《临床医学研究与实践》2024年第9期101-104,共4页Clinical Research and Practice

基　　金：陕西省自然科学基础研究计划项目(No.2022JM-610)。

摘　　要：目的探讨超声引导下细针穿刺细胞学检查(FNAC)联合细针穿刺洗脱液甲状腺球蛋白(FNA-Tg)在甲状腺乳头状癌(PTC)颈侧区淋巴结转移中的诊断价值。方法回顾性分析行颈侧区淋巴结清扫术的200例PTC患者的临床资料,术前超声评估颈侧区有可疑转移淋巴结236枚,术后病理证实转移性淋巴结178枚,非转移性淋巴结58枚,所有患者均行FNAC、FNA-Tg检查。以术后病理结果为金标准,比较FNAC、FNA-Tg、FNAC联合FNA-Tg的诊断结果及诊断效能。结果FNAC联合FNA-Tg诊断PTC颈侧区淋巴结转移的灵敏度、准确度、阴性预测值高于单一诊断方法,差异具有统计学意义(P<0.05)。结论FNAC与FNA-Tg检测方法在临床中能够用于诊断PTC颈侧区淋巴结转移,两者联合检测可以进一步提高诊断效能,值得推广及应用。Objective To investigate the diagnostic value of ultrasound-guided fine needle aspirate cytology(FNAC)combined with fine-needle aspiration washout thyroglobulin(FNA-Tg)in cervical lymph node metastasis of papillary thyroid carcinoma(PTC).Methods The clinical data of 200 PTC patients who underwent cervical lymph node dissection were retrospectively analyzed,and 236 suspicious metastatic lymph nodes were evaluated by preoperative ultrasound in the lateral cervical region.The 178 metastatic lymph nodes and 58 non-metastatic lymph nodes were confirmed by postoperative pathology,all patients underwent FNAC and FNA-Tg examinations.The diagnostic results and diagnostic efficacy of FNAC,FNA-Tg,FNAC combined with FNA-Tg were compared with postoperative pathological results as the gold standard.Results The sensitivity,accuracy and negative predictive value of the FNAC combined with FNA-Tg in diagnosing lymph node metastasis in the cervical region of PTC were higher than those of the single diagnostic method,and the differences were statistically significant(P<0.05).Conclusion FNAC and FNA-Tg detection methods can be used to diagnose cervical lymph node metastasis of PTC in clinical practice,and the combined detection can further improve the diagnostic efficiency,it is worthy of promotion and application.

关 键 词：细针穿刺细胞学检查 细针穿刺洗脱液甲状腺球蛋白 甲状腺乳头状癌 颈侧区淋巴结 转移 诊断效能 

分 类 号：R736.1[医药卫生—肿瘤]