TACE联合抗病毒治疗HBV相关性肝癌的预后观察及相关因素分析  

Prognostic Factors of TACE Combined with Antiviral Therapy for HBV-associated Hepatocellular Carcinoma

作　　者：宋娟丽 史娜[2] 刘峥[1] 冀青青 尹玉红 SONG Juan-li;SHI Na;LIU Zheng;JIQing-qing;YIN Yu-hong(The Third Department of Oncology,Handan Central Hospital,Handan,Hebei,056000,China;Department of Hepatology,Handan Infectious Diseases Hospital,Handan,Hebei,056000,China;Heping Street Community Health Service Center,Congtai District,Handan,Hebei,056000,China)

机构地区：[1]河北省邯郸市中心医院肿瘤三科,河北邯郸056000 [2]河北省邯郸市传染病医院肝四科,河北邯郸056000 [3]河北省邯郸市丛台区和平街道社区卫生服务中心,河北邯郸056000

出　　处：《现代生物医学进展》2023年第24期4786-4790,共5页Progress in Modern Biomedicine

基　　金：邯郸市科学技术研究与发展计划项目(1723208006ZC)。

摘　　要：目的:分析影响肝动脉化疗栓塞(TACE)联合抗病毒治疗乙型肝炎病毒(HBV)相关性肝癌预后的相关因素。方法:纳入的130例HBV相关性肝癌选自于本院2018年2月至2020年3月期间所收治,所有患者均行TACE联合抗病毒治疗,记录其生存情况,并对影响患者预后的相关因素进行分析与探讨。结果:130例患者随访截止时,死亡58例,存活72例,中位生存期为24个月,1年生存率为82.31%,2年生存率为55.38%;单因素及多因素Cox回归分析结果显示,肿瘤最大直径、血清AFP、Child-Pugh分级、腹腔转移、门静脉癌栓是患者预后不良的的危险因素。结论:肿瘤最大直径、血清AFP、Child-Pugh分级、腹腔转移、门静脉癌栓是影响TACE联合抗病毒治疗HBV相关性肝癌病患预后的影响因素。Objective:To analyze the prognostic factors of transarterial chemoembolization(TACE)combined with antiviral therapy for hepatitis B virus(HBV)-associated hepatocellular carcinoma.Methods:This study included 130 patients with HBV-associated hepatocellular carcinoma admitted to the hospital from February 2018 to March 2020.All patients underwent TACE combined with antiviral therapy,and their survival status was recorded.The prognostic factors were analyzed.Results:At the end of follow-up,58 patients died and 72 patients survived,with a median survival time of 24 months.The 1-year and 2-year survival rates were 82.31%and 55.38%.Univariate analysis and multivariate Cox regression analysis found that the maximum tumor diameter,serum AFP,Child-Pugh grade,abdominal cavity metastasis,and portal vein tumor thrombus were risk factors for poor prognosis.Conclusion:The maximum tumor diameter,serum AFP,Child-Pugh grade,abdominal cavity metastasis,and portal vein tumor thrombus are factors affecting the prognosis of HBV-associated hepatocellular carcinoma treated with TACE combined with antiviral therapy.

关 键 词：乙型肝炎病毒相关性肝癌 肝动脉化疗栓塞 抗病毒 预后 影响因素 

分 类 号：R735.7[医药卫生—肿瘤] R512.62[医药卫生—临床医学]