Nogo-A在神经系统疾病中的研究进展  

Research progress of Nogo-A in neurological diseases

作　　者：曲姜昆 姜俊杰[2] QU Jiangkun;JIANG Junjie(The Second School of Clinical Medicine of Binzhou Medical University,Yantai 264100,Shandong Province,China;Department of Orthopedics,Yantaishan Hospital,Yantai 264003,Shandong Province,China)

机构地区：[1]滨州医学院第二临床医学院,山东烟台264100 [2]烟台市烟台山医院骨科,山东烟台264003

出　　处：《数理医药学杂志》2024年第3期222-227,共6页Journal of Mathematical Medicine

摘　　要：神经生长抑制因子A(neurite outgrowth inhibitor A,Nogo-A)在哺乳动物中是一种能够抑制轴突生长的蛋白质。研究发现Nogo-A在神经系统中对轴突生长和突触可塑性起到调节作用,并与阿尔兹海默症、肌萎缩性侧索硬化症、多发性硬化症、脊髓损伤等密切相关。本文综述了Nogo-A及其受体NgR的基本结构、功能以及在神经系统疾病等方面的研究进展。The neunte outgrowth inhibitor A(Nogo-A)is a protein found in mammals,which is capable of inhibiting axon growth.Previous research has found that Nogo-A can play a regulatory role in axon growth and synaptic plasticity in the nervous system,and it is closely associated with Alzheimer's disease,amyotrophic lateral sclerosis,multiple sclerosis,and spinal cord injuries.This article reviewed the basic structure and functions of Nogo-A and its receptor NgR,as well as the research progress in the context of neurological disorders.

关 键 词：NOGO-A 神经系统疾病 神经退行性病变 脊髓损伤 

分 类 号：R741[医药卫生—神经病学与精神病学]