青岛市成年人腰围与缺血性脑卒中发病风险关联的前瞻性研究  

Association between waist circumference and ischemic stroke:a prospective study in adults from Qingdao

作　　者：李聿蕙 刘蕾[1] 胡丹 郑晓艳 吕筠[3,4,5] 余灿清[3,4,5] 裴培 段海平 高汝钦[6,7] 逄增昌 田小草[6,7] 孙点剑一 Li Yuhui;Liu Lei;Hu Dan;Zheng Xiaoyan;Lyu Jun;Yu Canqing;Pei Pei;Duan Haiping;Gao Ruqin;Pang Zengchang;Tian Xiaocao;Sun Dianjianyi(Department of Epidemiology and Biostatistics,School of Public Health,Qingdao University,Qingdao 266071,China;Licang District Center for Disease Control and Prevention of Qingdao,Qingdao 266041,China;Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Peking University Center for Public Health and Epidemic Preparedness&Response,Beijing 100191,China;Key Laboratory of Epidemiology of Major Diseases(Peking University),Ministry of Education,Beijing 100191,China;Qingdao Center for Disease Control and Prevention,Qingdao 266033,China;Qingdao Institute of Preventive Medicine,Qingdao 266033,China)

机构地区：[1]青岛大学公共卫生学院流行病与卫生统计学系,青岛266071 [2]青岛市李沧区疾病预防控制中心,青岛266041 [3]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [4]北京大学公众健康与重大疫情防控战略研究中心,北京100191 [5]重大疾病流行病学教育部重点实验室(北京大学),北京100191 [6]青岛市疾病预防控制中心,青岛266033 [7]青岛市预防医学研究院,青岛266033

出　　处：《中华流行病学杂志》2024年第2期178-184,共7页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(82192900,82192901,82192904,81390540,91846303,82103920);国家重点研发计划(2023YFC2509400);国家重点研发计划“精准医学研究”重点专项(2016YFC0900500);中国香港Kadoorie Charitable基金;英国Wellcome Trus(t 202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z);青岛市医疗卫生优秀人才培养项目。

摘　　要：目的分析腰围与缺血性脑卒中发病风险的关联。方法研究对象来自中国慢性病前瞻性研究青岛项目点。利用研究对象的基线信息和随访获得的缺血性脑卒中发病事件,采用Cox比例风险回归模型和限制性立方样条图(RCS)模型分析腰围与缺血性脑卒中发病风险的关联。结果共纳入研究对象33355名,累计随访302008.88人年,共有缺血性脑卒中新发病例1093名。Cox比例风险回归模型分析结果显示,与腰围正常组(男性<85.0 cm/女性<80.0 cm)相比,腰围超标组(男性≥85.0 cm/女性≥80.0 cm)发生缺血性脑卒中的风险升高了78%[风险比(HR)=1.78,95%CI:1.51~2.10],在男性和女性中分别升高了72%(HR=1.72,95%CI:1.40~2.12)和83%(HR=1.83,95%CI:1.40~2.39)。RCS模型分析显示,腰围与缺血性脑卒中发病风险呈非线性的“S”形剂量-反应关系。结论缺血性脑卒中发病风险随着腰围的增加而增加,维持正常腰围对于预防缺血性脑卒中具有重要意义。Objective To analyze the association between waist circumference(WC)and ischemic stroke(IS).Methods The data for the present study were from the prospective cohort study of China Kadoorie Biobank in Qingdao.Using baseline information and IS events of the participants,the Cox proportional hazard regression model and restricted cubic spline(RCS)were used to analyze the association between WC and IS.Results A total of 33355 participants were included in the study,with 302008.88 person-years of follow-up.A total of 1093 new cases of IS were observed.Multivariate Cox proportional hazard regression model analysis showed that compared to the respondents with normal WC(male<85.0 cm,female<80.0 cm),respondents with excessive WC(male≥85.0 cm,female≥80.0 cm)had a 78% higher risk of IS incidence[hazard ratio(HR)=1.78,95%CI:1.51-2.10],and the risk increased by 72%(HR=1.72,95%CI:1.40-2.12)and 83%(HR=1.83,95%CI:1.40-2.39)in men and women.According to the RCS,the increase in WC and the risk of IS showed an"S"trend of nonlinear dose-response relationship.Conclusions The risk of IS would increase with the WC.Keeping a normal WC is important for preventing IS.

关 键 词：缺血性脑卒中 腰围 前瞻性研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学]