浅谈癫痫的自身免疫机制  

Discussion on the autoimmune mechanism ofepilepsy

作　　者：肖波[1] 刘鼎[2] Xiao Bo;Liu Ding(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Neurology,the Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅医院神经内科,长沙410008 [2]中南大学湘雅三医院神经内科,长沙410013

出　　处：《中华神经科杂志》2024年第2期101-107,共7页Chinese Journal of Neurology

摘　　要：由自身免疫性病因引起的癫痫在临床实践中越来越常见。它们通常只对免疫治疗有反应,而单纯使用多种抗癫痫药物均难以控制发作,从而发展成药物难治性癫痫。因此,临床医生在病程早期识别癫痫的免疫性病因并进行针对性的免疫治疗至关重要。目前,自身免疫性癫痫的发病机制尚不清楚,也无规范的诊疗标准,未来需要更多大规模的基础研究和临床试验对癫痫的自身免疫机制进行深入研究。Epilepsy arising from autoimmune etiologies has become increasingly prevalent in clinical practice.These cases typically exhibit limited responsiveness to conventional antiepileptic drugs,often progressing into drug-resistant epilepsy.Consequently,the early identification of autoimmune causes of epilepsy and the subsequent implementation of targeted immunotherapy are of paramount significance for clinicians.Presently,the pathogenesis of autoimmune epilepsy remains elusive,and standardized diagnostic and therapeutic guidelines are lacking.It is imperative that future endeavors involve extensive large-scale foundational research and clinical trials to delve deeper into the autoimmune mechanisms underpinning epilepsy.

关 键 词：癫痫 自身免疫性疾病 抗体 免疫治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学]