Predictors of surgical complications in boys with hypospadias:data from an international registry  

作　　者：Kathryn Scougall Jillian Bryce Federico Baronio Rachel L Boal Jose Roberto Castera Sebastián Castro Tim Cheetham Eduardo Correa Costa Feyza Darendeliler Justin H Davies Mirjam Dirlewanger Gabriella Gazdagh Evgenia Globa Gil Guerra-Junior Tulay Guran Gloria Herrmann Paul-Martin Holterhus Ahsen KaragözlüAkgül Renata Markosyan Kenneth McElreavey Marcio Lopes Miranda Anna Nordenstrom Stuart O’Toole Sukran Poyrazoglu Gianni Russo Valerie Schwitzgebel Marianna Stancampiano Michael Steigert S Faisal Ahmed Angela K Lucas-Herald 

机构地区：[1]University of Glasgow,Glasgow,UK [2]IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola,Bologna,Italy [3]Great North Children's Hospital,Newcastle Upon Tyne,UK [4]Hospital de Ninos Ricardo Gutiérrez,Buenos Aires,Argentina [5]Hospital de Clinicas de Porto Alegre,Porto Alegre,Brazil [6]Istanbul University,Istanbul,Turkey [7]Southampton Children's Hospital,Southampton,UK [8]University Hospital of Geneva,Geneva,Switzerland [9]Ukrainian Research Center of Endocrine Surgery Endocrine Organs and Tissue Transplantation,Kyiv,Ukraine [10]State University of Campinas,Campinas,Brazil [11]Marmara University,Istanbul,Turkey [12]University Medical Centre,Ulm,Germany [13]University Hospital of Schleswig-Holstein Campus Kiel/Christian-Albrechts-University of Kiel,Kiel,Germany [14]Marmara University Faculty of Medicine,Istanbul,Turkey [15]Yerevan State Medical University Endocrinology Clinic,Yerevan,Armenia [16]Institut Pasteur,Paris,France [17]Karolinska University Hospital,Stockholm,Sweden [18]Royal Hospital for Children,Glasgow,UK [19]IRCCS Ospedale San Raffaele,Milano,Italy [20]Graubunden Cantonal Hospital,Chur,Switzerland

出　　处：《World Journal of Pediatric Surgery》2023年第4期217-223,共7页世界小儿外科杂志（英文）

基　　金：funded by Chief Scientist Office(PCL/21/05).

摘　　要：Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.Methods Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development(l-DSD)Registry.Logistic regressions,fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication rates.Results Of the 551 eligible boys,data were available on 160(29%).Within the cohort,the median(range)External Masculinization Score(EMS)was 6(2,9).All presented with one or more additional genital malformation and 61(38%)presented with additional extragenital malformations.Disorders of androgen action,androgen synthesis and gonadal development were diagnosed in 28(18%),22(14%)and 9(6%)boys,respectively.The remaining 101(62%)patients were diagnosedas having non-specific 46,XY Disorders of Sex Development.Eighty(50%)boys had evidence of abnormal biochemistry,and gene variants were identified in 42(26%).Median age at first hypospadias surgery was 2 years(0,9),and median length of follow-up was 5 years(0,17).Postsurgical complications were noted in 102(64%)boys.There were no significant associations with postsurgical complications.Conclusions Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications.No clinical factors were significantly associated with complication rates.High complication rates with no observable cause suggest the involvement of other factors which need investigation.

关 键 词：COMPLICATIONS SURGICAL INVOLVEMENT 

分 类 号：R726.9[医药卫生—儿科]