丹参酮ⅡA环糊精包合物的制备工艺研究  

Study on The Preparation of Tanshinone ⅡA and β-Cyclodextrin Inclusion Complex

作　　者：贾静 单士刚[2] 章康威 付晓俐 魏明杰 包永芬 黎威巍 迟恒[5] JIA Jing;SHAN Shi-gang;LI Wei-wei(School of Pharmacy,Xianning Medical College,Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]湖北科技学院医学部药学院,湖北咸宁437100 [2]湖北科技学院医学部公共卫生与健康学院 [3]湖北科技学院附属第二医院 [4]湖北科技学院医学部基础医学院 [5]江苏食品药品职业技术学院食品药品研究院

出　　处：《湖北科技学院学报（医学版）》2024年第2期114-117,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北科技学院校内科研发展基金项目附属第二医院专项(2021LCY001);湖北科技学院校内科研发展基金项目国家级科研项目培育计划项目(2020-22GP06)。

摘　　要：目的改善丹参酮ⅡA的水溶性。方法采用饱和水溶液法制备丹参酮ⅡA-β-环糊精包合物,研究时间、温度、质量比对收率的影响。用正交试验优化实验条件,接着用荧光光谱法对包合物进行表征,最后检测包合物水溶性。结果时间3h、温度55℃、丹参酮ⅡA与β-环糊精质量比1∶4为最佳制备条件,荧光光谱法证明了包合物的形成。与丹参酮ⅡA相比,包合物的溶解度提高了24.5倍。结论用饱和水溶液法制备丹参酮ⅡA-β-环糊精包合物,使丹参酮ⅡA溶解度得到了提高。Objective To improve the water solubility of tanshinoneⅡA.Methods The inclusion complex of tanshinoneⅡA andβ-Cyclodextrin was prepared by the saturated aqueous solution method,and the effects of time,temperature and mass ratio on the yield were studied.The optimal experimental conditions and times were determined by orthogonal experiments,and the inclusion complex was characterized by fluorescence spectroscopy and its water solubility was tested.Results The results showed that the best preparation conditions were 3 hours of time,55℃of temperature and 1∶4 of mass ratio between tanshinoneⅡA andβ-cyclodextrin.The fluorescence spectrometry confirmed the formation of the inclusion complex,and the water solubility of the inclusion complex was 24.5 times higher than that of tanshinoneⅡA.Conclusion The saturated aqueous solution method generates the inclusion complex of tanshinoneⅡA andβ-Cyclodextrin,and can significantly enhance the solubility of the inclusion complex.

关 键 词：丹参酮ⅡA Β-环糊精 饱和水溶液法 制备条件 溶解度 

分 类 号：R912[医药卫生—药学]