富硒小麦草牙膏对控制牙菌斑和减轻牙龈炎效果的临床研究  

Clinical Study on Effect of Selenium-enriched Wheat Grass Toothpaste on Reducing Gingival Inflammation and Controlling Dental Plaque

作　　者：皮小琴 朱彬 童国勇 李森森 赵国栋 张怡婷 杨再波 PI Xiaoqin;ZHU Bin;TONG Guoyong;LI Sensen;ZHAO Guodong;ZHANG Yiting;YANG Zaibo(Department of Stomatology,The Central Hospital of Enshi TuJia and Miao Autonomous Prefecture,Enshi 445002,China;Enshi Clinical College,Wuhan University.Enshi 445002,China;Hubei University of Medicine.Shiyan 442000,China)

机构地区：[1]恩施土家族苗族自治州中心医院口腔诊疗中心,湖北恩施445002 [2]武汉大学恩施临床学院,湖北恩施445002 [3]湖北医药学院,湖北十堰442000

出　　处：《口腔医学研究》2024年第3期233-235,共3页Journal of Oral Science Research

基　　金：2023年湖北省自然科学基金联合基金(编号:2023AFD073)。

摘　　要：目的:探讨富硒小麦草牙膏减轻牙龈炎症及控制牙菌斑作用的临床效果。方法:本临床试验遵守随机、对照、双盲的设计原则,按纳入和排除标准将年龄18~65岁间的72例受试者随机分成试验组和对照组,试验组使用富硒小麦草牙膏,对照组使用不含富硒小麦草其余成分完全相同的牙膏,分别在基线、1、3和6个月采用改良Loe-Silness牙龈指数、龈沟出血指数和改良Quigley-Hein菌斑指数评价牙周状况。结果:1、3和6个月时,牙龈指数试验组对照组均数计分分别为1.16±0.10和1.26±0.22,0.99±0.91和1.21±1.16,0.92±0.11和1.01±0.11;龈沟出血指数试验组对照组均数计分分别为1.12±0.23和1.24±0.27,1.05±0.11和1.13±0.15,0.91±0.12和1.05±0.09;牙菌斑指数试验组对照组均数计分分别为1.37±0.20和1.54±0.19,1.14±0.21和1.37±0.24,0.98±0.16和1.21±0.22,3个月和6个月时比较,差异有统计学意义(P<0.05)。说明其具有抑制牙菌斑和促进牙龈健康的作用。在本临床研究中未观察到不良反应,验证了富硒小麦草牙膏的安全性。结论:本研究提示富硒小麦草牙膏可以明显控制牙菌斑的形成,促进牙龈健康。Objective:To investigate the clinical impact of toothpaste enriched with selenium-rich wheat grass.Methods:Following the principles of randomized,double-blind,controlled design,72 participants aged 18 to 65 years were randomly assigned to either the experimental group(using selenium-rich wheat grass toothpaste)or the control group(using no selenium-rich wheat grass toothpaste).The gingival index,gingival bleeding index,and plaque index were evaluated at baseline,1 month,3 months,and 6 months after treatment.Results:At 1,3 and 6 months,the mean scores of gingival index in experimental group and control group were 1.16±0.10 and 1.26±0.22,0.99±0.91 and 1.21±1.16,0.92±0.11 and 1.01±0.11,respectively.The mean scores of gingival sulcus bleeding index in the experimental group and control group were 1.12±0.23 and 1.24±0.27,1.05±0.11 and 1.13±0.15,0.91±0.12 and 1.05±0.09,respectively.The mean scores of plaque index in the experimental group and control group were 1.37±0.20 and 1.54±0.19,1.14±0.21 and 1.37±0.24,0.98±0.16 and 1.21±0.22,respectively.Notably,no adverse effects were observed during this clinical study.Conclusion:Selenium-enriched wheat grass toothpaste significantly hampers dental plaque formation,alleviates gingivitis,and enhances gum health.

关 键 词：富硒小麦草 牙膏 牙龈炎症 牙菌斑 

分 类 号：R781.4[医药卫生—口腔医学]