HR-HPV载量与宫颈上皮内病变及宫颈癌相关性的研究进展  

Research progress on the relevance of HR-HPV load and cervical precancerous lesions and cervical cancer

作　　者：陈晓琳[1,2] 杨贞 Chen Xiaolin;Yang Zhen(Shantou University Medical College,Shantou 515036,China;Department of Gynaecology,Jieyang People's Hospital,Jieyang 522000,China)

机构地区：[1]汕头大学医学院,汕头515063 [2]揭阳市人民医院妇科,揭阳522000

出　　处：《国际医药卫生导报》2024年第6期932-935,共4页International Medicine and Health Guidance News

摘　　要：宫颈癌为全球第四大恶性肿瘤,且发病率正在不断上升。高危型人乳头瘤病毒(high risk human papilloma virus,HR-HPV)持续感染被认为是宫颈癌的主要致病因素。自2019年开始,很多权威机构都建议采用HPV DNA检测作为宫颈癌初筛手段。但是,这种方法会筛查出大量HPV阳性的女性,因此,准确识别宫颈癌高风险人群,并实施有效的管理很有必要。近来有研究表明,HR-HPV可能是宫颈病变病情进展的一个参考指标,但它们之间的关系仍不明确。因此,本文旨在深入探讨HR-HPV载量与宫颈病变严重程度之间的关系,以期有助于宫颈癌的早期诊断和早期治疗。Cervical cancer is the fourth most common cancer worldwide,and its incidence is rising.The most important risk factor for cervical cancer is persistent high risk human papilloma virus(HR-HPV)infection.Many authorities in the world have recommended that HPV DNA testing has been a method of cervical cancer preliminary screening since 2019.However,this method screens out a large number of HPV-positive women,so it is necessary to accurately identify the high-risk groups of cervical cancer and implement effective managements.Recent studies have shown that HR-HPV load may be a reference marker for the progression of cervical lesions,but the relationship between them is still not clear.The aim of this study is to investigate the relevance of HR-HPV load and cervical precancerous lesions and cervical cancer,and to improve the early diagnosis and treatment of cervical cancer.

关 键 词：高危型人乳头瘤病毒 病毒载量 宫颈上皮内病变 宫颈癌 进展 

分 类 号：R737.33[医药卫生—肿瘤]