血清瘦素水平与抑郁症的相关性研究  

Correlation Analysis between Serum Leptin Level and Depression

作　　者：严欢 冯毅菲 张培文 王子孝 程纬民[1] 曹美群[3] YAN Huan;FENG Yifei;ZHANG Peiwen;WANG Zixiao;CHENG Weimin;CAO Meiqun(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi Nanning 530023;Guangxi University of Chinese Medicine,Guangxi Nanning 530001;Shenzhen Second People's Hospital,Shenzhen Institute of Geriatrics,Guangdong Shenzhen 518035;Shandong Daizhuang Hospital,Shandong Jining 272000;Yunfu People′s Hospital,Guangdong Yunfu 527300)

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西中医药大学,广西南宁530001 [3]深圳市第二人民医院深圳市老年医学研究所,广东深圳518035 [4]山东省戴庄医院,山东济宁272000 [5]云浮市人民医院,广东云浮527300

出　　处：《深圳中西医结合杂志》2024年第1期7-10,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金项目(81503415);深圳市科技规划项目(JCYJ20210324122803011)。

摘　　要：目的:探讨抑郁症患者血清瘦素水平变化的临床意义。方法:选取2020年1月至2020年12月山东省戴庄医院收治的60例抑郁症患者和募集的30例健康志愿者为研究对象,抑郁症患者依照病情予常规口服抗抑郁药物治疗4周,采用汉密尔顿抑郁量表(HAMD)评估患者治疗前后抑郁症状的严重程度,采用酶联免疫吸附测定法(ELISA)测定健康志愿者和抑郁症患者治疗前后的血清瘦素水平,分析抑郁症患者血清瘦素水平的变化。结果:(1)抑郁症患者治疗后的HAMD评分较抑郁症患者治疗前下降,治疗总有效率为100.00%;(2)抑郁症患者治疗前的瘦素水平显著高于健康志愿者,且口服抗抑郁药物治疗后的瘦素水平显著高于治疗前,差异均具有统计学意义(P<0.01);(3)不同性别之间的瘦素水平比较,女性瘦素水平均高于相同组别和时间的男性瘦素水平,差异均具有统计学意义(P<0.01)。结论:(1)抑郁症患者的血清瘦素水平高于健康人群,且经口服抗抑郁治疗后血清瘦素水平进一步升高。(2)健康人群及抑郁症患者中女性的血清瘦素水平均高于相应状态下男性的血清瘦素水平。Objective To explore the clinical significance of changes in serum leptin levels in patients with depression.Methods Sixty depression patients and 30 recruited healthy volunteers admitted to Shandong Daizhuang Hospital from January 2020 to December 2020 were selected as the research subjects.Depression patients were treated with conventional oral antidepressant drugs for 4 weeks according to their condition.The severity of depression symptoms before and after treatment was evaluated using the Hamilton depression scale(HAMD).The serum leptin levels of healthy volunteers and depression patients before and after treatment were measured using enzyme-linked immunosorbent assay(ELISA),and the changes in serum leptin levels of depression patients were analyzed.Results(1)The HAMD score of depression patients after treatment was lower than that before treatment,and the total effective rate of 100.00%.(2)The levels of leptin in patients with depression before treatment were significantly higher than those in healthy volunteers,and the levels of leptin after oral antidepressant treatment were significantly higher than those before treatment,with statistical significance(P<0.01).(3)The comparison of leptin levels between different genders showed that female leptin levels were higher than male leptin levels in the same group and time,and the differences were statistically significant(P<0.01).Conclusion(1)Serum leptin levels in patients with depression are higher than those in healthy individuals,and serum leptin levels further increase after oral antidepressant treatment.(2)The serum leptin levels of women in healthy individuals and patients with depression are higher than those of men in corresponding states.

关 键 词：抑郁症 瘦素 酶联免疫吸附测定法 

分 类 号：R749.4[医药卫生—神经病学与精神病学]