HIV阳性女性宫颈高危HPV感染与宫颈病变的相关性分析  

Correlation analysis of cervical high-risk HPV infection and cervical lesions in HIV positive women

作　　者：李艳梅 张玉珍[1] 李秀兰[1] 周宇翔 侯颖 刘青[1] Li Yanmei;Zhang Yuzhen;Li Xiulan;Zhou Yuxiang;Hou Ying;Liu Qing(Department of Gynecology,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院妇科,100069

出　　处：《北京医学》2023年第12期1019-1022,共4页Beijing Medical Journal

基　　金：国家自然科学基金(82072271)。

摘　　要：目的 探讨HIV阳性女性宫颈高危型人乳头状瘤病毒(human papilloma virus, HPV)感染、宫颈液基薄层细胞学检测(thinprep cytologic test, TCT)及阴道镜病理分布特征,分析HIV感染与宫颈病变的关系。方法 选取2018年6月至2022年6月首都医科大学附属北京佑安医院妇科门诊患者75例,根据是否感染HIV分为观察组(33例)和对照组(42例)。比较两组TCT异常率、高危型HPV阳性率,分析HIV阳性女性宫颈高危HPV感染的宫颈病变临床特点。结果75例患者中,年龄20~59岁,平均(35.1±17.0)岁。两组TCT异常率、TCT筛查阴性HPV阳性行阴道镜下多点活检术后宫颈低级别病变及高级别病变率的比较,差异均无统计学意义(P>0.05)。观察组HPV阳性率及高危HPV阳性感染率高于对照组(97.0%比81.0%、93.9%比71.4%),差异均有统计学意义(P<0.05)。结论 HIV阳性女性合并HPV感染的风险及感染高危型HPV发生率较高。应重视HIV阳性女性宫颈筛查工作,应联合TCT及HPV筛查,加大宣传普及宫颈癌相关科普知识,一旦发现宫颈病变,应积极治疗,严密随访。Objective To explore the characteristics of cervical high-risk human papilloma virus(HPV)infection,thinprep cytologic test(TCT)and colposcopy pathological distribution in HIV-positive women,and the relationship between HIV infection and cervical lesions was analyzed.Methods A total of 75 gynecological outpatients in Beijing Youan Hospital Affiliated to Capital Medical University from June 2018 to June 2022 were selected and divided into observation group(33 cases)and control group(42 cases)according to whether they were infected with HIV.The abnormal rate of TCT and the positive rate of high-risk HPV were compared between the two groups,and the clinical characteristics of cervical lesions infected with high-risk HPV in HIV-positive women were analyzed.Results The age of 75 patients ranged from 20 to 59 years,with an average age of(35.1±17.0)years.There was no significant difference between the two groups in the abnormal rate of TCT,the rate of low-grade cervical lesions and the rate of high-grade cervical lesions after multi-point biopsy under colposcopy(P>0.05).The HPV positive rate and high-risk HPV positive infection rate in the observation group were higher than those in the control group(97.0%vs.81.0%,93.9%vs.71.4%),and the differences were statistically significant(P<0.05).Conclusions The risk of HIV-positive women with HPV infection and the incidence of high-risk HPV infection is higher.Attention should be paid to the cervical screening of HIV-positive women,combined with TCT and HPV screening,and the popularization of cervical cancer-related popular science knowledge should be increased.Once cervical lesions are found,they should be actively treated and closely followed up.

关 键 词：HIV 宫颈液基薄层细胞学检测 人乳头状瘤病毒 阴道镜下多点活检 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]