自噬在牙髓炎症进展和牙髓损伤修复再生中作用的研究进展  

Research progress in autophagy in the development of pulp inflammation and dental pulp injury reparation and regeneration

作　　者：韩燕霞 陈斌泽 闫茜起 郭艳 李健学 Han Yanxia;Chen Binze;Yan Qianqi;Guo Yan;Li Jianxue(Department of Stamotology,The 940th Hospital of Joint Logistics Support Force of Chinese Peoples Liberation Army,Lanzhou 730050,China;Department of Clinical Laboratory,Gansu Provincial Maternity and Child-care Hospital,Lanzhou 730050,China)

机构地区：[1]联勤保障部队第九四〇医院口腔科,兰州730050 [2]甘肃省妇幼保健院临床检验中心,兰州730050

出　　处：《中华口腔医学杂志》2024年第3期274-278,共5页Chinese Journal of Stomatology

基　　金：甘肃省自然科学基金(21JR11RA006,23JRRA530)。

摘　　要：牙髓炎是以牙髓组织持续性炎症和剧烈疼痛为特征的感染性疾病,根管治疗后易导致牙折、变色及再感染,因此牙髓损伤修复和牙髓再生成为牙髓疾病治疗的新目标。细胞自噬被认为是机体重要的防御和保护机制,在防止宿主过度炎症反应中起到重要作用。目前自噬在牙髓炎进展中的调控机制以及治疗相关的研究报道较少,本文就自噬在牙髓炎进展及其在牙髓损伤修复和牙髓再生中作用的相关研究进展做一综述,以期为进一步研究细胞自噬在牙髓疾病中的作用提供参考和理论支持。Pulpitis is an infectious disease characterized by persistent inflammation of dental pulp and severe pain of patients,root canal treatment increases the risk of tooth fracture,discoloration and reinfection.Therefore,pulp injury repair and pulp regeneration become the new targets of pulpitis treatment.Autophagy is considered as an important defense and protective mechanism,thus plays an important role in preventing the host from excessive inflammatory reaction.There are few reports on the regulative mechanisms and therapeutic strategies of autophagy on pulp inflammation progression,therefore,this paper reviewed the role of autophagy on the progression of pulpitis,also reviewed the research progress of autophagy on dental pulp injury repair and regeneration,aiming to provide theoretical support for further research and clinical application.

关 键 词：自噬 牙髓炎 牙髓损伤修复 牙髓再生 

分 类 号：R781.31[医药卫生—口腔医学]