血清高迁移率族蛋白B1、胱抑素C及白细胞介素-17联合检测对多发性骨髓瘤患者肾损伤的诊断价值  

The diagnostic value of combined detection of serum high mobility group protein B1,Cystatin C and Interleukin-17 for renal injury in patients with multiple myeloma

作　　者：杨春燕[1] 黄倩[1] 程盼盼[1] 陈璐璐[1] 贾燕 张顥 Yang Chunyan;Huang Qian;Cheng Panpan;Chen Lulu;Jia Yan;Zhang Hao(Department of Hematology,Affiliated Hospital of Jining Medical University,Jining 272000,China)

机构地区：[1]济宁医学院附属医院血液科,济宁272007

出　　处：《中华生物医学工程杂志》2023年第6期650-655,共6页Chinese Journal of Biomedical Engineering

基　　金：山东省自然科学基金青年项目(ZR2022OH239)。

摘　　要：探讨血清高迁移率族蛋白B1(HMGB1)、胱抑素C(CysC)及白细胞介素(IL)-17联合检测对多发性骨髓瘤(MM)患者肾损伤的诊断价值。研究发现血清HMGB1、CysC及IL-17在MM患者中异常高表达,且与病情进展及肾损伤存在密切联系,三者联合检测诊断MM患者并发肾损伤的效能较高。To investigate the diagnostic value of combined detection of serum high mobility group protein B1(HMGB1),cystatin C(CysC)and interleukin(IL)-17 for renal injury in patients with multiple myeloma(MM).The study shows abnormal high expression of serum HMGB1,CysC and IL-17 in MM patients is closely related to the progression of the disease and renal injury.The combined detection of the three has a high efficiency in the diagnosis of renal injury in MM patients.

关 键 词：多发性骨髓瘤 肾损伤 高迁移率族蛋白B1 胱抑素C 白细胞介素-17 

分 类 号：R733.3[医药卫生—肿瘤]