结肠癌患者中P53与FAT10的表达及临床意义  

Expression and clinical significance of P53 and FAT10 in patients with colon cancer

作　　者：张鵾 刘庆根 Zhang Kun;Liu Qinggen(Department of Gastrointestinal Surgery,Zhangqiu District People's Hospital,Jinan 250200,China)

机构地区：[1]山东省济南市章丘区人民医院胃肠外科,济南250200

出　　处：《国际免疫学杂志》2023年第6期636-641,共6页International Journal of Immunology

摘　　要：目的探讨结肠癌患者P53和FAT10蛋白的表达及临床意义。方法选取2018年1月至2019年12月在济南市章丘区人民医院行结肠癌根治术的75例患者为研究对象,检测切除标本中肿瘤组织、癌旁组织和正常结肠黏膜组织中FAT10和P53蛋白表达水平,分析两种蛋白在结肠癌发病中的意义。结果标本中正常结肠黏膜组织FAT蛋白及P53蛋白阳性率均低于癌旁组织和癌组织,差异有统计学意义(1.33%比10.67%比64.00%,1.33%比12.00%比65.33%,F值分别为90.65、91.16,P值均<0.05)。正常结肠黏膜组织中FAT10和P53蛋白染色评分均低于癌旁组织和结肠癌组织,差异有统计学意义[(0.17±0.02)比(0.67±0.11)比(4.33±0.99),(0.16±0.03)比(0.69±0.13)比(4.28±0.97),F值分别为1169.32、1179.07,P值均<0.05]。FAT10蛋白和P53蛋白阳性表达在癌症病灶分化程度、TNM分期、浸润深度和淋巴结转移等方面差异有统计学意义(P<0.05)。FAT蛋白阴性的2年存活率高于阳性患者(92.59%比70.88%,χ^(2)=4.88,P<0.05);P53蛋白阴性的2年存活率高于阳性患者(92.31%比71.43%,χ^(2)=4.41,P<0.05)。结论结肠癌组织中P53蛋白和FAT10蛋白高表达,对两种蛋白的检测可以预判结肠癌患者的恶性程度及预后情况。Objective To investigate the expression and clinical significance of P53 and FAT10 protein in patients with colon cancer.Methods A total 75 patients who underwent radical resection of colon cancer in Zhangqiu District People's Hospital from January 2018 to December 2019 were selected as the research objects.The protein expression levels of FAT10 and P53 in tumor tissues,adjacent tissues and normal colonic mucosa tissues in resected specimens were detected,and the significance of the proteins in the pathogenesis of colon cancer was analyzed.Results The positive rates of FAT protein and P53 protein in normal colon mucosa were significantly lower than those in adjacent tissues and cancer tissues(1.33%vs 10.67%vs 64.00%,1.33%vs 12.00%vs 65.33%,F=90.65,91.16,both P values<0.05).FAT10 and P53 protein staining scores in normal colonic mucosa tissues were lower than those in adjacent tissues and colon cancer tissues,and the differences were statistically significant[(0.17±0.02)vs(0.67±0.11)vs(4.33±0.99),(0.16±0.03)vs(0.69±0.13)vs(4.28±0.97),F values were 1169.32 and 1179.07,respectively,both P values<0.05].The positive expression of FAT10 protein and P53 protein had significant differences with the differentiation degree of cancer lesions,TNM stage,depth of invasion and lymph node metastasis(P<0.05).The 2-year survival rate of FAT protein negative was higher than that of FAT protein positive(92.59%vs 70.88%,χ^(2)=4.88,P<0.05).The 2-year survival rate of P53 negative was higher than that of P53 positive(92.31%vs 71.43%,χ^(2)=4.41,P<0.05).Conclusion The positive expressions of P53 and FAT10 protein in colon cancer tissues.The detection of two proteins can predict the malignancy and prognosis of colon cancer patients.

关 键 词：结肠癌 FAT10 P53蛋白 表达水平 临床意义 

分 类 号：R735.35[医药卫生—肿瘤]