免疫机制参与缺血性脑卒中损伤的研究进展  

Research progress of immune mechanism involved in ischemic stroke injury

作　　者：任彦学 于倩 赵琳琳[1] 张惊宇[1] Ren Yanxue;Yu Qian;Zhao Linlin;Zhang Jingyu(Department of Neurology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院神经内科,哈尔滨150001

出　　处：《国际免疫学杂志》2023年第6期684-688,共5页International Journal of Immunology

基　　金：国家自然科学基金(62272138);横向课题资助项目(委托方:沈阳安恒泰医疗科技有限公司,受托方:哈尔滨医科大学附属第四医院)(HX2020-12)。

摘　　要：缺血性脑卒中占所有脑卒中类型的75%~80%,是导致全球脑血管病发病与死亡的主要原因。目前缺血性脑卒中发生后进行静脉溶栓及动脉取栓治疗仍是首选治疗方案,然而严格的时间窗及适应症和昂贵的治疗方案让不少患者望而却步,因此研究人员仍在寻找其他有效的治疗方案。其中进行缺血性脑卒中后的免疫治疗已经成为了一个突破性方向,进一步揭示缺血性脑卒中发生后的免疫机制十分重要。在缺血性脑卒中发生后的每一个炎症反应阶段都与特定的免疫反应有关,两者密不可分。文章综述了缺血性脑卒中免疫反应激活及相关免疫机制,总结潜在免疫靶点,为缺血性脑卒中提供免疫治疗策略。Ischemic stroke accounts for 75%~80%of all stroke types and is the main cause of global cerebrovascular disease incidence and death.After ischemic stroke occurs,intravenous thrombolysis and arterial thrombectomy are still the preferred treatment options.However,strict time windows,indications,and expensive treatment plans for arterial thrombectomy have left many patients disappointed.Therefore,researchers are still searching for other effective treatment options,among which immunotherapy after ischemic stroke has become a breakthrough direction.Therefore,it is important to further reveal the immune mechanism after ischemic stroke,and each inflammatory response stage after ischemic stroke is related to a specific immune response,which is inseparable.This paper reviewed the activation of immune response and related immune mechanisms in ischemic stroke,summarizes potential immune targets,and provides immunotherapy strategies for ischemic stroke.

关 键 词：缺血性脑卒中 免疫机制 免疫治疗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]