不同钙化程度的狭窄颈动脉血管和血流的流固耦合研究  

Fluid-Structure Interaction Study of Stenosed Carotid Artery and Blood Flow with Different Degrees of Calcification

作　　者：胡梦超 焦淑平 吴鉴今 曲乐丰 陈红勋[1] 代钦[1] Hu Mengchao;Jiao Shuping;Wu Jianjin;Qu Lefeng;Chen Hongxun;Daichin(Shanghai Institute of Applied Mathematics and Mechanics,School of Mechanics and Engineering Science,Shanghai University,Shanghai 200072,China;Department of Vascular and Endovascular Surgery,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China)

机构地区：[1]上海大学力学与工程科学学院,上海市应用数学和力学研究所,上海200072 [2]海军军医大学第二附属医院血管外科,上海200003

出　　处：《水动力学研究与进展（A辑）》2023年第6期956-964,共9页Chinese Journal of Hydrodynamics

基　　金：上海市科学技术委员会2021年度“科技创新行动计划”基础研究领域项目(21JC1406500)。

摘　　要：该文基于双向流固耦合计算,评估了不同钙化程度下的狭窄颈动脉血管壁的壁面剪切力(WSS)以及粥样斑块内部各组分的受力情况,探究了钙化程度对于斑块破裂的影响。依据一名患有颈动脉狭窄病人的CT影像数据进行三维建模,建立血管壁模型和包含脂质核心、钙化以及纤维组织在内的多组分斑块模型,并在此基础上建立不同钙化程度的斑块模型,进行流固耦合计算和对比分析。结果表明:随着钙化程度提高,血管壁表面整体的WSS分布无明显差异,但动脉狭窄处的WSS有小幅度减小,降低了斑块表皮破裂的风险,且在钙化的后期,降低幅度趋于稳定;随着钙化程度提高,钙化自身以及斑块内其他组分,如:纤维帽、脂质核心等的应力和应变逐渐降低,其中纤维帽的应力和应变大幅度降低,使得斑块内部在一定程度上更加稳定,不容易发生破裂;钙化程度越高,带斑块一侧的血管壁的应力及应变逐渐增大,而对不带斑块一侧的血管壁并无显著影响。该文的研究结果有助于进一步理解钙化问题对于斑块力学环境的影响。Based on the two-way fluid-structure interaction,in this paper,the wall shear stress(WSS)of the stenosis carotid artery wall and the stress of each component in the atherosclerotic plaque under different degrees of calcification is evaluated,and the impact of the degree of calcification on plaque rupture is explored.Three-dimensional modeling was performed on the CT image data of a patient with carotid artery stenosis,and the vascular wall model and multi-component plaque model including lipid core,calcification and fibrous tissue are established.On this basis,plaque models with different calcification degrees are established,and fluid-structure coupling calculation and comparative analysis are performed.The results show that for the higher the degree of calcification,there is no significant difference in the overall WSS distribution on the surface of the vascular wall.However,the WSS at the stenosis decreases a little,reducing the risk of plaque epidermal rupture.In the later stage of calcification,the range of decrease tends to stabilize.With the higher the degree of calcification,the stress and strain of calcification and other components in the plaque,fiber cap,lipid core,etc.would be reduced.The stress and strain of the fiber cap are significantly reduced,making the interior of the plaque more stable to a certain extent and less prone to rupture.For the higher the degree of calcification,the stress and strain of the vascular wall with plaque increases,but it has little effect on the vascular wall without plaque.The results of this study are helpful to further understand the influence of calcification on the plaque mechanical environment.

关 键 词：粥样斑块 斑块破裂 斑块钙化 流固耦合 

分 类 号：R543.4[医药卫生—心血管疾病]