1990—2019年中国鼻咽癌疾病负担及变化趋势分析  

Analysis on the disease burden and change trend of nasopharyngeal carcinoma in China from 1990 to 2019

作　　者：吴秀强 杨珍[1] 杜韫雨 谢志勤 陈诗涵 易林霞 王泽权 戴小华[1] WU Xiuqiang;YANG Zhen;DU Yunyu;XIE Zhiqin;CHEN Shihan;YI Linxia;WAN Zequan;DAI Xiaohua(The First Affiliated Hospital of Nanchang University,Nanchang,Jiangxi Province 330000,China;School of Nursing,Nanchang University,Nanchang,Jiangxi Province 330000,China)

机构地区：[1]南昌大学第一附属医院,江西省南昌330000 [2]南昌大学护理学院,江西省南昌330000

出　　处：《中国慢性病预防与控制》2023年第12期902-906,共5页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：江西省科技厅重点研发项目(20192BBGL70016);江西省教育厅科学技术研究项目(GJJ190047);江西省研究生创新专项项目(YC2021-S197)。

摘　　要：目的了解1990—2019年中国鼻咽癌疾病负担和变化趋势,为鼻咽癌的防治提供科学参考。方法数据来源于2019年全球疾病负担(GBD 2019)数据库,提取1990—2019年中国鼻咽癌的发病率、死亡率、早死所致寿命损失年(YLL)率、伤残所致寿命损失年(YLD)率、伤残调整寿命年(DALY)率及其标化率。采用Joinpoint 4.9.0.1软件计算平均年度变化百分比(AAPC)。结果1990—2019年,中国鼻咽癌标化发病率由3.308/10万上升至5.653/10万(AAPC=1.804%),标化YLD率由1.351/10万上升至3.294/10万(AAPC=3.097%),但标化死亡率、标化YLL率和标化DALY率均呈下降趋势(AAPC分别为-2.454%、-2.603%和-2.394%)。1990—2019年,中国男性鼻咽癌各项疾病负担指标均显著高于女性,女性的标化死亡率、标化YLL率和标化DALY率(AAPC分别为-3.498%、-3.740%和-3.536%)下降幅度均大于男性(AAPC分别为-1.958%、-2.116%和-1.898%)。2019年,85岁及以上年龄组鼻咽癌的发病率、死亡率和YLD率均为最高,YLL率在70~74岁年龄组最高,DALY率在65~69岁年龄组最高。结论1990—2019年,中国鼻咽癌的死亡率有所下降,但发病率仍呈持续上升趋势,疾病负担较重。应加强中老年人群鼻咽癌的防治工作,重点关注男性人群。Objective To understand the disease burden and change trend of nasopharyngeal carcinoma in China from 1990 to 2019,and provide the scientific reference for the prevention and treatment of nasopharyngeal cancer.Methods The data were from“the 2019 Global Burden of Disease Database(GBD 2019)”,the incidence,mortality,years of life lost(YLL)rate,years lived with disability(YLD)rate,disability-adjusted life years(DALY)rate,and their standardized rates for nasopharyngeal carcinoma in China from 1990 to 2019 were extracted.Joinpoint 4.9.0.1 software was used to calculate the average annual percent change(AAPC),and to analyze the disease burden and change trend of nasopharyngeal cancer in China.Results From 1990 to 2019,the standardized incidence rate of nasopharyngeal cancer in China increased from 3.308/105 to 5.653/105(AAPC=1.804%),and the standardized YLD rate increased from 1.351/105 to 3.294/105(AAPC=3.097%);but the standardized mortality rate,standardized YLL rate,and standardized DALY rate showed the downward trend(AAPC values were-2.454%,-2.603%and-2.394%).From 1990 to 2019,the all indexes of disease burden of nasopharyngeal cancer disease in males were significantly higher than those of females,the decline of standardized mortality rate,standardized YLL rate and standardized DALY rate(AAPC values were-3.498%,-3.740%and-3.536%)in females was higher than that(AAPC values were-1.958%,-2.116%and-1.898%)of males in China.In 2019,the nasopharyngeal cancer incidence,mortality and YLD rates in≥85 years old group were the highest,YLL rate in 70-74 years old group was the highest,DALY rate in 65-69 years old group was the highest.Conclusion From 1990 to 2019,the mortality rate of nasopharyngeal cancer in China declined.The incidence of nasopharyngeal cancer showed upward trend and heavy disease burden.It should strengthen the prevention and treatment for nasopharyngeal cancer in middle aged and elderly people,and pay attention to males.

关 键 词：鼻咽癌 疾病负担 伤残调整寿命年 趋势分析 

分 类 号：R739.63[医药卫生—肿瘤]