Advances in molecular mechanisms of oral submucosal fibrogenic carcinogenesis  

作　　者：LI Bing-xia WEN Qi-tao WANG Tao SUN Guan-yu FU Xiao SU Shou-da 

机构地区：[1]School of Stomatology,Hainan Medical University,Haikou 571199,China [2]Department of Stomatology,Hainan General Hospital,Haikou 570311,China

出　　处：《Journal of Hainan Medical University》2023年第23期74-78,共5页海南医学院学报（英文版）

基　　金：National Natural Science Foundation of China(No.81960199);Major Science and Technology Plan and Key R&D Plan Project of Hainan Province(No.ZDYF2021SHFZ114);Hainan Provincial Department of Health Project(No.22A200001)。

摘　　要：Oral submucosal fibrosis(OSF)is a chronic,progressive and insidious oral mucosal disease.Its development is highly associated with areca chewing and eventually evolves into oral squamous cell carcinoma(OSCC),which is currently recognized as a precancerous state by the International Center for Research on Cancer(IARC).Due to the extremely complex carcinogenesis process of OSF,the carcinogenesis mechanism is not clear,and most scholars believe that the disease is the result of multiple factors.Therefore,this paper mainly summarized the latest research on the molecular mechanism of OSF canceration,aiming at understanding the law of OSF canceration and providing theoretical reference for early detection,diagnosis and treatment of OSF canceration.

关 键 词：Oral submucous fibrosis CARCINOGENESIS MECHANISM 

分 类 号：R781.5[医药卫生—口腔医学]