Clinical observation on the efficacy and safety of different doses of alfentanil for painless gastroscopy  

作　　者：ZHANG Jiao CHEN Rui LI Yuan XIE Hai WANG Shan 

机构地区：[1]Department of Anesthesiology,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,China

出　　处：《Journal of Hainan Medical University》2023年第18期51-55,共5页海南医学院学报（英文版）

基　　金：Hubei Chen Xiaoping Science and Technology Development Foundation for Perioperative analgesic Afentanil Special Fund(No.CXPJJH12000010);Health Industry Research Project of Hainan Province(No.20A200263)。

摘　　要：Objective:To observe the Effective dose and safety of different doses of alfentanil combined with propofol in painless gastroscopy.Method:240 patients who underwent painless gastric examination from January 2021 to December 2021 were randomly divided into a control group and a different dose group of alfentanil(N1 group,N2 group,N3 group,N4 group,and N5 group,with injection doses of 5,6,7,8,and 10ug/kg,respectively)using a number table method,with 40 patients in each group.The control group was anesthetized with propofol injection,while different dosage groups of alfentanil were anesthetized with different doses of alfentanil combined with propofol.Evaluate the anesthesia effect after the examination is completed.Compare the heart rate(HR),systolic blood pressure(SBP),apnea time,incidence of intolerance to gastroscopy insertion,and adverse reactions in each group.Result:Compared with before administration,SBP and HR in all groups decreased before gastroscopy placement(P<0.01);At 1 minute after gastroscopy insertion,both SBP and HR in the control group increased(P<0.01),while SBP in the N3 and N4 groups decreased(P<0.01),while HR remained unchanged(P>0.05).Both SBP and HR in the N5 group decreased(P<0.01).Compared with before gastroscopy insertion,SBP and HR in the control group,N1,N2,and N3 groups increased 1 minute after gastroscopy insertion(P<0.01),while there was no significant change in SBP and HR in the N4 and N5 groups(P>0.05).The apnea time of different dosage groups of alfentanil was lower than that of the control group(P<0.01),and the apnea time of N5 group was higher than that of N1 group,N2 group,N3 group,and N4 group(P<0.01).There was no significant difference in the Incidence of intolerant reactions during gastroscopy insertion,cough reaction,retching reflex,swallowing reflex and limb movement reaction rate between the six groups(P>0.05);There was no statistically significant difference in the incidence of itching,nausea,vomiting,anxiety,dizziness,drowsiness,diarrhea,and constipation after painless

关 键 词：Afentanil Painless gastroscopy EFFECTIVENESS SECURITY Vital signs Adverse reaction 

分 类 号：R573[医药卫生—消化系统]