Research progress on the effects of phthalates on reproductive health of childbearing population and their offspring  

作　　者：LIN Cai-yun YIN Fei-fei WANG Hui-zi YANG Hua 

机构地区：[1]Women and Children’s Medical Center of Hainan Province,Haikou 570206,China [2]Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou 571199,China [3]Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,Hainan Medical University,Haikou 571199,China

出　　处：《Journal of Hainan Medical University》2023年第16期61-68,共8页海南医学院学报（英文版）

基　　金：Hainan Province Clinical Medical Center (No.QWYH202175).

摘　　要：The total fertility rate of women in childbearing age showed a downward trend in China.In addition to the age and genetic factors,environmental endocrine disruption can also impair fertility.The impact of increasing new environmental pollutants on the couples in childbearing age has become a research hotspot recently.Phthalate acid esters(PAEs)is a common plasticizer in plastic products,which is widely found in toys,food packaging,construction materials,electronic and medical components,personal care products,office and school supplies and other plastic packaging products,and is the main substance of environmental pollution.Multiple studies have shown that PAEs can not only cause environmental and water pollution,but also have a variety of toxic effects such as reproductive toxicity,genotoxicity,immunotoxicity,neurotoxicity,teratogenicity,and carcinogenesis.Therefore,its impact on human health,especially on reproductive health of people of reproductive age and their offspring,cannot be ignored.However,the current epidemiological study of PAEs and new alternatives in reproductive health population is still controversial,and the toxicity mechanism is still in the exploration stage.This article through to PAEs of parental generation,children(including embryo)of reproductive development and the influence of genetic toxicity research progress at home and abroad to do a review,aims to promote effective control measures for the establishment of PAEs pollutants rather than on reproductive health risk prediction,thus for PAEs of adverse reproductive outcomes of reproductive stage of people provide a scientific basis for precision control and guidance.

关 键 词：PAES People of reproductive age Reproduction toxicity GENOTOXICITY 

分 类 号：R114[医药卫生—卫生毒理学]