Research progress in the efficacy of deep brain stimulation with different targets in Parkinson's disease  

作　　者：AI Xiang-bai HUANG Xiao-gan WANG Yi-tian LI Jun-ju ZHAO Jian-nong 

机构地区：[1]Hainan Medical University,Haikou 571199,China [2]Hainan General Hospital,Haikou 570311,China

出　　处：《Journal of Hainan Medical University》2023年第21期53-59,共7页海南医学院学报（英文版）

基　　金：Natural Science Foundation of Hainan Province (No.821RC682)。

摘　　要：Parkinson's disease(PD)is a chronic progressive neurodegenerative disease.Deep brain stimulation(DBS)is an effective treatment for patients with advanced PD.There are many DBS targets for PD,including subthalamic nucleus(STN),globus pallidus(GPi),meso-ventral thalamic nucleus(VIM),pontine peduncle nucleus(PPN),posterior subthalamic region(PSA)and zonation of undetermined zone(ZI).This paper summarizes the efficacy of each target in the treatment of PD with DBS,not only makes a systematic analysis and comparison of motor symptoms,but also makes a detailed description of the efficacy of non-motor symptoms,so as to provide a personalized treatment basis for PD patients to select appropriate target targets in DBS.

关 键 词：Parkinson's disease Deep brain stimulation Subthalamic nucleus Globus pallidus Ventral thalamic nucleus Pontine peduncle nucleus Posterior subthalamic areas Zonation of undetermined zone 

分 类 号：R742.5[医药卫生—神经病学与精神病学]