翻译调控在纤维化发生中的作用进展  

Research progress on translational regulation in fibrosis

作　　者：陈伟 彭金梅 聂开瑜 Chen Wei;Peng Jinmei;Nie Kaiyu(Department of Burns and Plastic Surgery,Affiliated Hospital of Zunyi Medical University,The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University,Zunyi Guizhou 563003,China;Department of Burns and Plastic Surgery,Tongren People’s Hospital,Tongren Guizhou 554300,China)

机构地区：[1]遵义医科大学附属医院烧伤整形外科,遵义医科大学组织损伤修复与再生医学省部共建协同创新中心,贵州遵义563003 [2]铜仁市人民医院烧伤整形外科,贵州铜仁554300

出　　处：《遵义医科大学学报》2024年第3期313-322,共10页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81660325);省部共建协同创新中心项目[NO:教科技厅函(2020)39]。

摘　　要：目前纤维化疾病的治疗仍是世界性难题,其带来的医疗负担不容小觑。纤维化疾病病因涉及创伤、感染、代谢或自身免疫等多方面,研究发现纤维化疾病有着共同的病理基础,但尚未阐明其具体的分子机制。由于蛋白质是生物学行为的重要参与者,因此在翻译水平探究纤维化疾病的分子机制可能是有效的研究方案。本综述基于数据平台(PubMed、Web of science等)检索文献,回顾近5年关于翻译水平调控纤维化的分子机制研究进展,拟通过总结推动人们对纤维化分子机制的认识。我们总结了在翻译的起始、延伸以及终止阶段对纤维化的发生有重要影响的因子。例如翻译起始因子家族的在翻译起始过程中的关键影响,延伸因子在肽链延伸过程中的重要作用,正确识别终止密码子在翻译终止过程中的重要意义。除此之外,我们还总结了其他在翻译水平有重要作用的因子,例如微小RNA、转运RNA、小核糖体RNA及长非编码RNA等。At present,the treatment of fibrotic diseases is still a worldwide problem,and the medical burden caused by fibrotic diseases cannot be underestimated.Its etiology involves trauma,infection,metabolism or autoimmunity.Studies have found that fibrotic diseases have a common pathological basis.However,its molecular mechanism cannot be elucidated at present.Given the crucial role of proteins in biological processes,investigating the translational level may offer an effective research approach to unravel the molecular mechanisms of fibrotic diseases.This review is based on comprehensive literature retrieval from data platforms such as PubMed and Web of Science.Its objective is to provide an overview of recent advancements in translationally regulated molecular mechanism of fibrosis over the past five years and enhance our understanding in this field.We summarize the factors that play important roles in the initiation,elongation and termination of translation in the development of fibrosis.For example,the key role of the eukaryotic initiation factor family in translation initiation,the important role of elongation factors in peptide chain elongation,and the importance of correct recognition of stop codons in translation termination.In addition,we also summarize other important factors at the level of translation,such as miRNA,tRNA,tsRNA and lcnRNA.

关 键 词：纤维化 蛋白质合成 翻译水平调控 

分 类 号：R364.3[医药卫生—病理学]