尿路上皮癌患者化疗期间营养风险及影响因素研究  

Study on nutritional risk and influencing factors of patients with urothelial carcinoma during chemotherapy

作　　者：李慧慧 陈慧[1] 王良梅[1] 张小青 Li Huihui;Chen Hui;Wang Liangmei;Zhang Xiaoqing(Department of Urology Nanjing Drum Tower Hospital,Nanjing 210008,Jiangsu,China)

机构地区：[1]南京鼓楼医院泌尿外科,江苏南京210008

出　　处：《肿瘤代谢与营养电子杂志》2024年第1期60-64,共5页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：南京鼓楼医院院级课题(2022-B1288)。

摘　　要：目的探讨尿路上皮癌患者化疗期间营养状况,并分析其影响因素。方法选取南京鼓楼医院2021年1月至2023年1月泌尿外科收治的尿路上皮癌患者180例。采用营养风险筛查2002(NRS 2002)量表评估患者入院24 h内营养风险,并对尿路上皮癌患者化疗期间营养状况的影响因素进行单因素分析与多因素Logistic回归分析。结果经NRS 2002评估,180例患者中存在营养风险者73例,占40.56%,无营养风险者107例,占59.44%。存在营养风险者血清总蛋白、血清白蛋白水平均低于无营养风险者(P<0.05)。经单因素分析可见,存在营养风险者年龄、体质量指数、家庭人均月收入、临床分期,以及抑郁、呕吐、手术构成比与无营养风险者比较,差异有统计学意义(P<0.05)。经多因素Logistic回归分析可见,年龄、家庭人均月收入、临床分期、抑郁、呕吐、血清总蛋白水平、血清白蛋白水平是影响尿路上皮癌患者化疗期间营养状况的危险因素(P<0.05)。结论年龄、家庭人均月收入、临床分期、抑郁、呕吐、血清总蛋白水平、血清白蛋白水平是影响尿路上皮癌患者化疗期间营养状况的主要因素。Objective To investigate the nutritional status of patients with urothelial carcinoma during chemotherapy and analyze its influencing factors.Method From Janwary 2021 to January 2023,180 patients with urotbelial carcinoma admitted to the urological department in our hospital were selected.Nutritional risk screening 2002(NRS 2002)was used to ssess the nutritional risk of patients within 24 hours of admission,and univariate analysis and multivariate logistic regression analysis were conducted to analyze the influencing factors of nutritional status of patients with urothelial carcinoma during chemotherapy.Result According to NRS 2002 evaluation,73 out of 180 patients had nutritional risk,accounting for 40.56%,and 107 out of 180 patients had no nutritional risk,accounting for 59.44%.The serum total protein and albumin levels of individuals with nutritional risk were lower than those without nutritional risk(P<0.05).Through univariate analysis,it can be seen that there is a staitically significant difference in age,body mass index,per capita monthly income of families,clinical staging,depression,voniting,and surgical proportion between individuals at nutritional risk and those without nutritional risk(P<0.05).Through multiple factor analysis,it can be seen that age,per capita monthly income of the family,clinical stage,depression,vomiting,serum total protein,and serum albumin levels are independent risk factors that afect the mutritional status of patients with urotbelial carcinoma during chemotherapy(P<0.05).Condusion Age,average monthly family income,clinical stage,depression,vomniting,serum total protein and serum albumin levels are the main factors afting the nutitional status of patients with wrothelium cancer during chemotherapy.

关 键 词：尿路上皮癌 化疗 营养状况 影响因素 

分 类 号：R737.1[医药卫生—肿瘤] R459.3[医药卫生—临床医学]