情绪调节的神经环路及其在情绪障碍人群中的表现  

Neural Circuits of Emotion Regulation and Their Performance in Patients with Emotional Disorders

作　　者：张丹丹[1] 李思瑾 ZHANG Dandan;LI Sijin(Institute of Brain and Psychological Sciences,Sichuan Normal University,Chengdu 610066,Sichuan)

机构地区：[1]四川师范大学脑与心理科学研究院,四川成都610066

出　　处：《四川师范大学学报（自然科学版）》2024年第3期285-293,F0002,共10页Journal of Sichuan Normal University（Natural Science）

基　　金：国家自然科学基金(32271102和31920103009);深港脑科学创新研究院基金(2021SHIBS0003)。

摘　　要：情绪调节是影响个体身心健康的重要适应性功能,而情绪失调是情绪障碍患者的跨诊断特征,是其病因和症状维持的关键因素.结合经典的情绪调节过程模型,首先综述情绪调节的神经环路,发现外侧前额叶是构成情绪调节神经环路的关键脑区.不同调节策略对应不尽相同的脑网络:分心策略需要背外侧前额叶、顶叶完成注意转换;重新解释策略依赖负责语言加工的腹外侧前额叶、颞叶;分离策略需要颞顶联合区调整心理距离;表达抑制策略依赖前脑岛整合情绪与身体意识、辅助运动区控制外在情绪表达.接着总结情绪障碍患者情绪失调的关键脑节点,发现患者均表现出外侧前额叶功能失调:抑郁和双相情感障碍以外侧前额叶与杏仁核的功能连接减弱为关键脑功能损伤,焦虑障碍在情绪调节过程中表现出额-顶区注意控制网络激活降低.建议未来研究结合“脑调控+脑观测”技术进一步揭示情绪调节的神经环路,开展旨在提高情绪障碍患者情绪调节能力的临床治疗研究.The ability to regulate our emotions is essential for our mental and physical health as well as successful social interaction.And emotion dysregulation is considered a trans-diagnostic characteristic in the development and recurrence of emotional disorders.This paper,integrating classical models of emotion regulation,initiates by scrutinizing the neural circuits involved in emotion regulation.The lateral prefrontal cortex functions as a crucial brain region constituting these circuits.Various regulation strategies correspond to distinct brain networks:distraction strategies involve the dorsolateral prefrontal cortex and parietal regions for attentional shifts;reinterpretation strategies rely on the ventrolateral prefrontal cortex and temporal regions responsible for language processing;de-tachment strategies engage the temporo-parietal junction for adjusting psychological distance;expressive suppression strategies depend on the anterior insula for integrating emotion and bodily awareness,and the supplementary motor area for controlling outward emotional expression.Then we summarized the key brain nodes of emotions dysregulation in patients with depression disorder,bipolar disorder,and anxiety disorder.Dysregulation in the lateral prefrontal cortex function consistently appears across various emotional disorders:de-pression and bipolar disorder exhibit weakened functional connectivity between the lateral prefrontal cortex and the amygdala,while anxiety disorders manifest reduced activation in the fronto-parietal attention control network during emotion regulation.We propose that future research,employing a combination of“brain modulation+brain observation”technologies,should further elucidate the neural circuits of emotion regulation.Additionally,clinical treatment studies aiming to enhance emotion regulation capabilities in individuals with emotional disorders are recommended.

关 键 词：情绪调节 神经环路 前额叶 抑郁障碍 双相情感障碍 焦虑障碍 

分 类 号：B842[哲学宗教—基础心理学]