补体系统:缺血性卒中患者卒中后认知损害的可能干预靶点  

Complement system:possible intervention targets for post-stroke cognitive impairment in patients with ischemic stroke

作　　者：吴雅煖 刘凌云[2] 李梦凡[2] 李雪梅[3] 张金彪[2] 李振光[2] Wu Yaxuan;Liu Lingyun;Li Mengfan;Li Xuemei;Zhang Jinbiao;Li Zhenguang(Weifang Medical University,Weifang 261053,China;Department of Neurology,Weihai Municipal Hospital,Weihai 264200,China;Department of Neurology,the Affiliated Hospital of Weifang Medical University,Weifang 261031,China)

机构地区：[1]潍坊医学院,潍坊261053 [2]威海市立医院神经内科,威海264200 [3]潍坊医学院附属医院神经内科,潍坊261031

出　　处：《国际脑血管病杂志》2023年第11期857-861,共5页International Journal of Cerebrovascular Diseases

摘　　要：卒中后认知损害(post stroke cognitive impairment,PSCI)是指卒中后出现并达到认知损害诊断标准且持续6个月以上的临床综合征,严重影响着患者的日常生活。补体系统已被证实与PSCI相关。文章对补体系统与PSCI的相关性以及补体系统作为PSCI干预靶点的可能性进行了综述。Post-stroke cognitive impairment(PSCI)refers to a clinical syndrome that occurs after a stroke and meets the diagnostic criteria for cognitive impairment,lasting for more than 6 months,and seriously affecting the daily life of patients.The complement system has been confirmed to be associated with PSCI.This article reviews the correlation between complement system and PSCI,as well as the possibility of complement system as an intervention target for PSCI.

关 键 词：卒中 脑缺血 认知障碍 补体系统蛋白质类 炎症 神经元可塑性 血脑屏障 神经保护药 

分 类 号：R743.3[医药卫生—神经病学与精神病学]